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Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382865/ https://www.ncbi.nlm.nih.gov/pubmed/30787307 http://dx.doi.org/10.1038/s41467-019-08469-7 |
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| author | Daya, Michelle Rafaels, Nicholas Brunetti, Tonya M. Chavan, Sameer Levin, Albert M. Shetty, Aniket Gignoux, Christopher R. Boorgula, Meher Preethi Wojcik, Genevieve Campbell, Monica Vergara, Candelaria Torgerson, Dara G. Ortega, Victor E. Doumatey, Ayo Johnston, Henry Richard Acevedo, Nathalie Araujo, Maria Ilma Avila, Pedro C. Belbin, Gillian Bleecker, Eugene Bustamante, Carlos Caraballo, Luis Cruz, Alvaro Dunston, Georgia M. Eng, Celeste Faruque, Mezbah U. Ferguson, Trevor S. Figueiredo, Camila Ford, Jean G. Gan, Weiniu Gourraud, Pierre-Antoine Hansel, Nadia N. Hernandez, Ryan D. Herrera-Paz, Edwin Francisco Jiménez, Silvia Kenny, Eimear E. Knight-Madden, Jennifer Kumar, Rajesh Lange, Leslie A. Lange, Ethan M. Lizee, Antoine Maul, Pissamai Maul, Trevor Mayorga, Alvaro Meyers, Deborah Nicolae, Dan L. O’Connor, Timothy D. Oliveira, Ricardo Riccio Olopade, Christopher O. Olopade, Olufunmilayo Qin, Zhaohui S. Rotimi, Charles Vince, Nicolas Watson, Harold Wilks, Rainford J. Wilson, James G. Salzberg, Steven Ober, Carole Burchard, Esteban G. Williams, L. Keoki Beaty, Terri H. Taub, Margaret A. Ruczinski, Ingo Mathias, Rasika A. Barnes, Kathleen C. |
| author_facet | Daya, Michelle Rafaels, Nicholas Brunetti, Tonya M. Chavan, Sameer Levin, Albert M. Shetty, Aniket Gignoux, Christopher R. Boorgula, Meher Preethi Wojcik, Genevieve Campbell, Monica Vergara, Candelaria Torgerson, Dara G. Ortega, Victor E. Doumatey, Ayo Johnston, Henry Richard Acevedo, Nathalie Araujo, Maria Ilma Avila, Pedro C. Belbin, Gillian Bleecker, Eugene Bustamante, Carlos Caraballo, Luis Cruz, Alvaro Dunston, Georgia M. Eng, Celeste Faruque, Mezbah U. Ferguson, Trevor S. Figueiredo, Camila Ford, Jean G. Gan, Weiniu Gourraud, Pierre-Antoine Hansel, Nadia N. Hernandez, Ryan D. Herrera-Paz, Edwin Francisco Jiménez, Silvia Kenny, Eimear E. Knight-Madden, Jennifer Kumar, Rajesh Lange, Leslie A. Lange, Ethan M. Lizee, Antoine Maul, Pissamai Maul, Trevor Mayorga, Alvaro Meyers, Deborah Nicolae, Dan L. O’Connor, Timothy D. Oliveira, Ricardo Riccio Olopade, Christopher O. Olopade, Olufunmilayo Qin, Zhaohui S. Rotimi, Charles Vince, Nicolas Watson, Harold Wilks, Rainford J. Wilson, James G. Salzberg, Steven Ober, Carole Burchard, Esteban G. Williams, L. Keoki Beaty, Terri H. Taub, Margaret A. Ruczinski, Ingo Mathias, Rasika A. Barnes, Kathleen C. |
| author_sort | Daya, Michelle |
| collection | PubMed |
| description | Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12–q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations. |
| format | Online Article Text |
| id | pubmed-6382865 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-63828652019-02-22 Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations Daya, Michelle Rafaels, Nicholas Brunetti, Tonya M. Chavan, Sameer Levin, Albert M. Shetty, Aniket Gignoux, Christopher R. Boorgula, Meher Preethi Wojcik, Genevieve Campbell, Monica Vergara, Candelaria Torgerson, Dara G. Ortega, Victor E. Doumatey, Ayo Johnston, Henry Richard Acevedo, Nathalie Araujo, Maria Ilma Avila, Pedro C. Belbin, Gillian Bleecker, Eugene Bustamante, Carlos Caraballo, Luis Cruz, Alvaro Dunston, Georgia M. Eng, Celeste Faruque, Mezbah U. Ferguson, Trevor S. Figueiredo, Camila Ford, Jean G. Gan, Weiniu Gourraud, Pierre-Antoine Hansel, Nadia N. Hernandez, Ryan D. Herrera-Paz, Edwin Francisco Jiménez, Silvia Kenny, Eimear E. Knight-Madden, Jennifer Kumar, Rajesh Lange, Leslie A. Lange, Ethan M. Lizee, Antoine Maul, Pissamai Maul, Trevor Mayorga, Alvaro Meyers, Deborah Nicolae, Dan L. O’Connor, Timothy D. Oliveira, Ricardo Riccio Olopade, Christopher O. Olopade, Olufunmilayo Qin, Zhaohui S. Rotimi, Charles Vince, Nicolas Watson, Harold Wilks, Rainford J. Wilson, James G. Salzberg, Steven Ober, Carole Burchard, Esteban G. Williams, L. Keoki Beaty, Terri H. Taub, Margaret A. Ruczinski, Ingo Mathias, Rasika A. Barnes, Kathleen C. Nat Commun Article Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12–q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations. Nature Publishing Group UK 2019-02-20 /pmc/articles/PMC6382865/ /pubmed/30787307 http://dx.doi.org/10.1038/s41467-019-08469-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Daya, Michelle Rafaels, Nicholas Brunetti, Tonya M. Chavan, Sameer Levin, Albert M. Shetty, Aniket Gignoux, Christopher R. Boorgula, Meher Preethi Wojcik, Genevieve Campbell, Monica Vergara, Candelaria Torgerson, Dara G. Ortega, Victor E. Doumatey, Ayo Johnston, Henry Richard Acevedo, Nathalie Araujo, Maria Ilma Avila, Pedro C. Belbin, Gillian Bleecker, Eugene Bustamante, Carlos Caraballo, Luis Cruz, Alvaro Dunston, Georgia M. Eng, Celeste Faruque, Mezbah U. Ferguson, Trevor S. Figueiredo, Camila Ford, Jean G. Gan, Weiniu Gourraud, Pierre-Antoine Hansel, Nadia N. Hernandez, Ryan D. Herrera-Paz, Edwin Francisco Jiménez, Silvia Kenny, Eimear E. Knight-Madden, Jennifer Kumar, Rajesh Lange, Leslie A. Lange, Ethan M. Lizee, Antoine Maul, Pissamai Maul, Trevor Mayorga, Alvaro Meyers, Deborah Nicolae, Dan L. O’Connor, Timothy D. Oliveira, Ricardo Riccio Olopade, Christopher O. Olopade, Olufunmilayo Qin, Zhaohui S. Rotimi, Charles Vince, Nicolas Watson, Harold Wilks, Rainford J. Wilson, James G. Salzberg, Steven Ober, Carole Burchard, Esteban G. Williams, L. Keoki Beaty, Terri H. Taub, Margaret A. Ruczinski, Ingo Mathias, Rasika A. Barnes, Kathleen C. Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations |
| title | Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations |
| title_full | Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations |
| title_fullStr | Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations |
| title_full_unstemmed | Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations |
| title_short | Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations |
| title_sort | association study in african-admixed populations across the americas recapitulates asthma risk loci in non-african populations |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382865/ https://www.ncbi.nlm.nih.gov/pubmed/30787307 http://dx.doi.org/10.1038/s41467-019-08469-7 |
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