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Sex differences in the (1)H NMR metabolic profile of serum in cardiovascular risk patients

Personalized diagnosis and risk stratification of cardiovascular diseases would allow optimizing therapeutic strategies and lifestyle changes. Metabolomics is a promising technique for personalized diagnosis and prognosis; however, various physiological parameters, including sex, influence the metab...

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Autores principales: Barba, Ignasi, Andrés, Mireia, Picón, Irene, Aguade-Bruix, Santiago, Garcia-Dorado, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382944/
https://www.ncbi.nlm.nih.gov/pubmed/30787362
http://dx.doi.org/10.1038/s41598-019-38881-4
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author Barba, Ignasi
Andrés, Mireia
Picón, Irene
Aguade-Bruix, Santiago
Garcia-Dorado, David
author_facet Barba, Ignasi
Andrés, Mireia
Picón, Irene
Aguade-Bruix, Santiago
Garcia-Dorado, David
author_sort Barba, Ignasi
collection PubMed
description Personalized diagnosis and risk stratification of cardiovascular diseases would allow optimizing therapeutic strategies and lifestyle changes. Metabolomics is a promising technique for personalized diagnosis and prognosis; however, various physiological parameters, including sex, influence the metabolic profile thus hampering its translation to the clinic. Knowledge of the variation in the metabolic profile associated with sex would facilitate metabolomic translation to the clinic. The objective of the present work was to investigate the possible differences in the metabolic (1)H NMR profile associated to sex beyond lipoproteins. (1)H NMR spectra from whole serum and methanol deproteinized samples from 39 patients (22 males, 17 females) between 55–70 years old with suspected coronary artery disease that underwent a stress test that was considered negative where included. Deproteinized serum could be used to differentiate sex based on higher levels of lactate and glucose in women. Lipoprotein region was the most variable area of the spectra between individuals, but spectra of whole serum were able to differentiate sex based on lipoproteins. There are sex-related differences in the (1)H NMR metabolic profile of individuals with suspected cardiovascular disease beyond lipoproteins. These findings may help the translation of metabolomics to the clinic.
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spelling pubmed-63829442019-02-25 Sex differences in the (1)H NMR metabolic profile of serum in cardiovascular risk patients Barba, Ignasi Andrés, Mireia Picón, Irene Aguade-Bruix, Santiago Garcia-Dorado, David Sci Rep Article Personalized diagnosis and risk stratification of cardiovascular diseases would allow optimizing therapeutic strategies and lifestyle changes. Metabolomics is a promising technique for personalized diagnosis and prognosis; however, various physiological parameters, including sex, influence the metabolic profile thus hampering its translation to the clinic. Knowledge of the variation in the metabolic profile associated with sex would facilitate metabolomic translation to the clinic. The objective of the present work was to investigate the possible differences in the metabolic (1)H NMR profile associated to sex beyond lipoproteins. (1)H NMR spectra from whole serum and methanol deproteinized samples from 39 patients (22 males, 17 females) between 55–70 years old with suspected coronary artery disease that underwent a stress test that was considered negative where included. Deproteinized serum could be used to differentiate sex based on higher levels of lactate and glucose in women. Lipoprotein region was the most variable area of the spectra between individuals, but spectra of whole serum were able to differentiate sex based on lipoproteins. There are sex-related differences in the (1)H NMR metabolic profile of individuals with suspected cardiovascular disease beyond lipoproteins. These findings may help the translation of metabolomics to the clinic. Nature Publishing Group UK 2019-02-20 /pmc/articles/PMC6382944/ /pubmed/30787362 http://dx.doi.org/10.1038/s41598-019-38881-4 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Barba, Ignasi
Andrés, Mireia
Picón, Irene
Aguade-Bruix, Santiago
Garcia-Dorado, David
Sex differences in the (1)H NMR metabolic profile of serum in cardiovascular risk patients
title Sex differences in the (1)H NMR metabolic profile of serum in cardiovascular risk patients
title_full Sex differences in the (1)H NMR metabolic profile of serum in cardiovascular risk patients
title_fullStr Sex differences in the (1)H NMR metabolic profile of serum in cardiovascular risk patients
title_full_unstemmed Sex differences in the (1)H NMR metabolic profile of serum in cardiovascular risk patients
title_short Sex differences in the (1)H NMR metabolic profile of serum in cardiovascular risk patients
title_sort sex differences in the (1)h nmr metabolic profile of serum in cardiovascular risk patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382944/
https://www.ncbi.nlm.nih.gov/pubmed/30787362
http://dx.doi.org/10.1038/s41598-019-38881-4
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