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Decreased retinal nerve fiber layer thickness in patients with cerebral venous thrombosis

BACKGROUND: To identify thickness variations in the retinal nerve fiber layer around the optic disc and macula in patients with cerebral vein thrombosis (CVT) without papilledema. METHODS: This study included 28 patients with CVT diagnosis and appropriate treatment. Detailed ophthalmologic examinati...

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Autores principales: Koban, Yaran, Ozlece, Hatice, Karayol, Sibel, Huseyinoglu, Nergiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383271/
https://www.ncbi.nlm.nih.gov/pubmed/30786862
http://dx.doi.org/10.1186/s12886-019-1046-9
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author Koban, Yaran
Ozlece, Hatice
Karayol, Sibel
Huseyinoglu, Nergiz
author_facet Koban, Yaran
Ozlece, Hatice
Karayol, Sibel
Huseyinoglu, Nergiz
author_sort Koban, Yaran
collection PubMed
description BACKGROUND: To identify thickness variations in the retinal nerve fiber layer around the optic disc and macula in patients with cerebral vein thrombosis (CVT) without papilledema. METHODS: This study included 28 patients with CVT diagnosis and appropriate treatment. Detailed ophthalmologic examination found bilateral vision 10/10, vision field test normal and fundus examination found no papilledema images. The patients had macular and optic retinal nerve fiber layer thickness (RNFL) measured with spectral domain-optical coherence tomography (SD-OCT) (Optovue, Fremont, CA). Patients had retinal nerve fiber thickness compared with a control group. RESULTS: When the effect on the macula and RNFL near the optic nerve disk is investigated, there was significant thinning identified in the macula inferior inner, temporal inner, superior inner and temporal outer quadrants (p = 0.009, 0.001, 0.026, 0.014, respectively) and in the inferior temporal quadrant of the optic nerve disk (p = 0.020) in CVT patients compared to normal individuals. CONCLUSIONS: Even after appropriate treatment of CVT patients, axonal loss was identified with OCT. As a result, it may be important to use OCT measurements to monitor CVT treatment.
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spelling pubmed-63832712019-03-01 Decreased retinal nerve fiber layer thickness in patients with cerebral venous thrombosis Koban, Yaran Ozlece, Hatice Karayol, Sibel Huseyinoglu, Nergiz BMC Ophthalmol Research Article BACKGROUND: To identify thickness variations in the retinal nerve fiber layer around the optic disc and macula in patients with cerebral vein thrombosis (CVT) without papilledema. METHODS: This study included 28 patients with CVT diagnosis and appropriate treatment. Detailed ophthalmologic examination found bilateral vision 10/10, vision field test normal and fundus examination found no papilledema images. The patients had macular and optic retinal nerve fiber layer thickness (RNFL) measured with spectral domain-optical coherence tomography (SD-OCT) (Optovue, Fremont, CA). Patients had retinal nerve fiber thickness compared with a control group. RESULTS: When the effect on the macula and RNFL near the optic nerve disk is investigated, there was significant thinning identified in the macula inferior inner, temporal inner, superior inner and temporal outer quadrants (p = 0.009, 0.001, 0.026, 0.014, respectively) and in the inferior temporal quadrant of the optic nerve disk (p = 0.020) in CVT patients compared to normal individuals. CONCLUSIONS: Even after appropriate treatment of CVT patients, axonal loss was identified with OCT. As a result, it may be important to use OCT measurements to monitor CVT treatment. BioMed Central 2019-02-20 /pmc/articles/PMC6383271/ /pubmed/30786862 http://dx.doi.org/10.1186/s12886-019-1046-9 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Koban, Yaran
Ozlece, Hatice
Karayol, Sibel
Huseyinoglu, Nergiz
Decreased retinal nerve fiber layer thickness in patients with cerebral venous thrombosis
title Decreased retinal nerve fiber layer thickness in patients with cerebral venous thrombosis
title_full Decreased retinal nerve fiber layer thickness in patients with cerebral venous thrombosis
title_fullStr Decreased retinal nerve fiber layer thickness in patients with cerebral venous thrombosis
title_full_unstemmed Decreased retinal nerve fiber layer thickness in patients with cerebral venous thrombosis
title_short Decreased retinal nerve fiber layer thickness in patients with cerebral venous thrombosis
title_sort decreased retinal nerve fiber layer thickness in patients with cerebral venous thrombosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383271/
https://www.ncbi.nlm.nih.gov/pubmed/30786862
http://dx.doi.org/10.1186/s12886-019-1046-9
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