Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells

BACKGROUND: Protein recoding by RNA editing is required for normal health and evolutionary adaptation. However, de novo induction of RNA editing in response to environmental factors is an uncommon phenomenon. While APOBEC3A edits many mRNAs in monocytes and macrophages in response to hypoxia and int...

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Detalles Bibliográficos
Autores principales: Sharma, Shraddha, Wang, Jianmin, Alqassim, Emad, Portwood, Scott, Cortes Gomez, Eduardo, Maguire, Orla, Basse, Per H., Wang, Eunice S., Segal, Brahm H., Baysal, Bora E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383285/
https://www.ncbi.nlm.nih.gov/pubmed/30791937
http://dx.doi.org/10.1186/s13059-019-1651-1

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