Role of self-organising myddosome oligomers in inflammatory signalling by Toll-like receptors

A paper published in BMC Biology characterises biophysically oligomeric and filamentous structures formed spontaneously by the Toll-like receptor signalling adaptor MyD88. Naturally occurring mutants of MyD88 that cause immunodeficiency are unable to form these structures. By contrast a somatic muta...

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Detalles Bibliográficos
Autor principal: Gay, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383289/
https://www.ncbi.nlm.nih.gov/pubmed/30786893
http://dx.doi.org/10.1186/s12915-019-0637-5
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author Gay, Nicholas J.
author_facet Gay, Nicholas J.
author_sort Gay, Nicholas J.
collection PubMed
description A paper published in BMC Biology characterises biophysically oligomeric and filamentous structures formed spontaneously by the Toll-like receptor signalling adaptor MyD88. Naturally occurring mutants of MyD88 that cause immunodeficiency are unable to form these structures. By contrast a somatic mutant that promotes the survival of tumour cells forms oligomers much more readily than the wild-type protein. These findings suggest that assembly of oligomeric MyD88 is critical for the regulation of inflammatory signalling.
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spelling pubmed-63832892019-03-01 Role of self-organising myddosome oligomers in inflammatory signalling by Toll-like receptors Gay, Nicholas J. BMC Biol Commentary A paper published in BMC Biology characterises biophysically oligomeric and filamentous structures formed spontaneously by the Toll-like receptor signalling adaptor MyD88. Naturally occurring mutants of MyD88 that cause immunodeficiency are unable to form these structures. By contrast a somatic mutant that promotes the survival of tumour cells forms oligomers much more readily than the wild-type protein. These findings suggest that assembly of oligomeric MyD88 is critical for the regulation of inflammatory signalling. BioMed Central 2019-02-20 /pmc/articles/PMC6383289/ /pubmed/30786893 http://dx.doi.org/10.1186/s12915-019-0637-5 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Gay, Nicholas J.
Role of self-organising myddosome oligomers in inflammatory signalling by Toll-like receptors
title Role of self-organising myddosome oligomers in inflammatory signalling by Toll-like receptors
title_full Role of self-organising myddosome oligomers in inflammatory signalling by Toll-like receptors
title_fullStr Role of self-organising myddosome oligomers in inflammatory signalling by Toll-like receptors
title_full_unstemmed Role of self-organising myddosome oligomers in inflammatory signalling by Toll-like receptors
title_short Role of self-organising myddosome oligomers in inflammatory signalling by Toll-like receptors
title_sort role of self-organising myddosome oligomers in inflammatory signalling by toll-like receptors
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383289/
https://www.ncbi.nlm.nih.gov/pubmed/30786893
http://dx.doi.org/10.1186/s12915-019-0637-5
work_keys_str_mv AT gaynicholasj roleofselforganisingmyddosomeoligomersininflammatorysignallingbytolllikereceptors

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