Cholesterol content in cell membrane maintains surface levels of ErbB2 and confers a therapeutic vulnerability in ErbB2-positive breast cancer

BACKGROUND: ErbB2 overexpression identifies a subset of breast cancer as ErbB2-positive and is frequently associated with poor clinical outcomes. As a membrane-embedded receptor tyrosine kinase, cell surface levels of ErbB2 are regulated dynamically by membrane physical properties. The present study...

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Detalles Bibliográficos
Autores principales: Zhang, Jinrui, Li, Qiong, Wu, Yueguang, Wang, Duchuang, Xu, Lu, Zhang, Yang, Wang, Shanshan, Wang, Taishu, Liu, Fang, Zaky, Mohamed Y., Hou, Shuai, Liu, Shuyan, Zou, Kun, Lei, Haixin, Zou, Lijuan, Zhang, Yingqiu, Liu, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383291/
https://www.ncbi.nlm.nih.gov/pubmed/30786890
http://dx.doi.org/10.1186/s12964-019-0328-4

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