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Cortical and Subcortical Contributions to Neuroplasticity after Repetitive Transspinal Stimulation in Humans

The objectives of this study were to establish cortical and subcortical contributions to neuroplasticity induced by noninvasive repetitive transspinal stimulation in human subjects free of any neurological disorder. To meet our objectives, before and after 40 minutes of transspinal stimulation we es...

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Detalles Bibliográficos
Autores principales: Murray, Lynda M., Islam, Md. Anamul, Knikou, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383395/
https://www.ncbi.nlm.nih.gov/pubmed/30881443
http://dx.doi.org/10.1155/2019/4750768
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author Murray, Lynda M.
Islam, Md. Anamul
Knikou, Maria
author_facet Murray, Lynda M.
Islam, Md. Anamul
Knikou, Maria
author_sort Murray, Lynda M.
collection PubMed
description The objectives of this study were to establish cortical and subcortical contributions to neuroplasticity induced by noninvasive repetitive transspinal stimulation in human subjects free of any neurological disorder. To meet our objectives, before and after 40 minutes of transspinal stimulation we established changes in tibialis anterior (TA) motor-evoked potentials (MEPs) in response to paired transcranial magnetic stimulation (TMS) pulses at interstimulus intervals (ISIs) consistent with I-wave periodicity. In order to establish to what extent similar actions are exerted at the spinal cord and motor axons, changes in soleus H-reflex and transspinal evoked potential (TEP) amplitude following transspinal and group Ia afferent conditioning stimulation, respectively, were established. After 40 min of transspinal stimulation, the TA MEP consecutive peaks of facilitation produced by paired TMS pulses were significantly decreased supporting for depression of I-waves. Additionally, the soleus H-reflex and ankle TEP depression following transspinal and group Ia afferent conditioning stimulation was potentiated at intervals when both responses interacted at the spinal cord and nerve axons. These findings support the notion that repetitive transspinal stimulation decreases corticocortical inputs onto corticospinal neurons and promotes a surround inhibition in the spinal cord and nerve axons. This novel method may be a suitable neuromodulation tool to alter excitability at cortical and subcortical levels in neurological disorders.
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spelling pubmed-63833952019-03-17 Cortical and Subcortical Contributions to Neuroplasticity after Repetitive Transspinal Stimulation in Humans Murray, Lynda M. Islam, Md. Anamul Knikou, Maria Neural Plast Research Article The objectives of this study were to establish cortical and subcortical contributions to neuroplasticity induced by noninvasive repetitive transspinal stimulation in human subjects free of any neurological disorder. To meet our objectives, before and after 40 minutes of transspinal stimulation we established changes in tibialis anterior (TA) motor-evoked potentials (MEPs) in response to paired transcranial magnetic stimulation (TMS) pulses at interstimulus intervals (ISIs) consistent with I-wave periodicity. In order to establish to what extent similar actions are exerted at the spinal cord and motor axons, changes in soleus H-reflex and transspinal evoked potential (TEP) amplitude following transspinal and group Ia afferent conditioning stimulation, respectively, were established. After 40 min of transspinal stimulation, the TA MEP consecutive peaks of facilitation produced by paired TMS pulses were significantly decreased supporting for depression of I-waves. Additionally, the soleus H-reflex and ankle TEP depression following transspinal and group Ia afferent conditioning stimulation was potentiated at intervals when both responses interacted at the spinal cord and nerve axons. These findings support the notion that repetitive transspinal stimulation decreases corticocortical inputs onto corticospinal neurons and promotes a surround inhibition in the spinal cord and nerve axons. This novel method may be a suitable neuromodulation tool to alter excitability at cortical and subcortical levels in neurological disorders. Hindawi 2019-02-07 /pmc/articles/PMC6383395/ /pubmed/30881443 http://dx.doi.org/10.1155/2019/4750768 Text en Copyright © 2019 Lynda M. Murray et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Murray, Lynda M.
Islam, Md. Anamul
Knikou, Maria
Cortical and Subcortical Contributions to Neuroplasticity after Repetitive Transspinal Stimulation in Humans
title Cortical and Subcortical Contributions to Neuroplasticity after Repetitive Transspinal Stimulation in Humans
title_full Cortical and Subcortical Contributions to Neuroplasticity after Repetitive Transspinal Stimulation in Humans
title_fullStr Cortical and Subcortical Contributions to Neuroplasticity after Repetitive Transspinal Stimulation in Humans
title_full_unstemmed Cortical and Subcortical Contributions to Neuroplasticity after Repetitive Transspinal Stimulation in Humans
title_short Cortical and Subcortical Contributions to Neuroplasticity after Repetitive Transspinal Stimulation in Humans
title_sort cortical and subcortical contributions to neuroplasticity after repetitive transspinal stimulation in humans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383395/
https://www.ncbi.nlm.nih.gov/pubmed/30881443
http://dx.doi.org/10.1155/2019/4750768
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