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Purification of mRNA Encoding Chimeric Antigen Receptor Is Critical for Generation of a Robust T-Cell Response

T cells made with messenger RNA (mRNA) encoding chimeric antigen receptor (CAR) offer a safe alternative to those transduced with viral CARs by mitigating the side effects of constitutively active T cells. Previous studies have shown that mRNA CAR T cells are transiently effective but lack persisten...

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Detalles Bibliográficos
Autores principales:	Foster, Jessica B., Choudhari, Namrata, Perazzelli, Jessica, Storm, Julie, Hofmann, Ted J., Jain, Payal, Storm, Phillip B., Pardi, Norbert, Weissman, Drew, Waanders, Angela J., Grupp, Stephan A., Karikó, Katalin, Resnick, Adam C., Barrett, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc., publishers 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383579/ https://www.ncbi.nlm.nih.gov/pubmed/30024272 http://dx.doi.org/10.1089/hum.2018.145

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