KLF4 Regulates Corneal Epithelial Cell Cycle Progression by Suppressing Canonical TGF-β Signaling and Upregulating CDK Inhibitors P16 and P27

PURPOSE: Krüppel-like factor 4 (KLF4) promotes corneal epithelial (CE) cell fate while suppressing mesenchymal properties. TGF-β plays a crucial role in cell differentiation and development, and if dysregulated, it induces epithelial-mesenchymal transition (EMT). As KLF4 and TGF-β regulate each othe...

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Detalles Bibliográficos
Autores principales: Tiwari, Anil, Swamynathan, Sudha, Alexander, Nicholas, Gnalian, John, Tian, Shenghe, Kinchington, Paul R., Swamynathan, Shivalingappa K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2019
Materias:
Cornea
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383833/
https://www.ncbi.nlm.nih.gov/pubmed/30786277
http://dx.doi.org/10.1167/iovs.18-26423

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