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Casting a wider net: Immunosurveillance by nonclassical MHC molecules

Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition of a wide variety of nonclassical MHC molecules. T...

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Autores principales: D’Souza, M. Patricia, Adams, Erin, Altman, John D., Birnbaum, Michael E., Boggiano, Cesar, Casorati, Giulia, Chien, Yueh-hsiu, Conley, Anthony, Eckle, Sidonia Barbara Guiomar, Früh, Klaus, Gondré-Lewis, Timothy, Hassan, Namir, Huang, Huang, Jayashankar, Lakshmi, Kasmar, Anne G., Kunwar, Nina, Lavelle, Judith, Lewinsohn, David M., Moody, Branch, Picker, Louis, Ramachandra, Lakshmi, Shastri, Nilabh, Parham, Peter, McMichael, Andrew J., Yewdell, Jonathan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383864/
https://www.ncbi.nlm.nih.gov/pubmed/30789961
http://dx.doi.org/10.1371/journal.ppat.1007567
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author D’Souza, M. Patricia
Adams, Erin
Altman, John D.
Birnbaum, Michael E.
Boggiano, Cesar
Casorati, Giulia
Chien, Yueh-hsiu
Conley, Anthony
Eckle, Sidonia Barbara Guiomar
Früh, Klaus
Gondré-Lewis, Timothy
Hassan, Namir
Huang, Huang
Jayashankar, Lakshmi
Kasmar, Anne G.
Kunwar, Nina
Lavelle, Judith
Lewinsohn, David M.
Moody, Branch
Picker, Louis
Ramachandra, Lakshmi
Shastri, Nilabh
Parham, Peter
McMichael, Andrew J.
Yewdell, Jonathan W.
author_facet D’Souza, M. Patricia
Adams, Erin
Altman, John D.
Birnbaum, Michael E.
Boggiano, Cesar
Casorati, Giulia
Chien, Yueh-hsiu
Conley, Anthony
Eckle, Sidonia Barbara Guiomar
Früh, Klaus
Gondré-Lewis, Timothy
Hassan, Namir
Huang, Huang
Jayashankar, Lakshmi
Kasmar, Anne G.
Kunwar, Nina
Lavelle, Judith
Lewinsohn, David M.
Moody, Branch
Picker, Louis
Ramachandra, Lakshmi
Shastri, Nilabh
Parham, Peter
McMichael, Andrew J.
Yewdell, Jonathan W.
author_sort D’Souza, M. Patricia
collection PubMed
description Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition of a wide variety of nonclassical MHC molecules. These include αβ and γδ T cells that recognize different class Ib molecules (CD1, MR-1, HLA-E, G, F, et al.) that are nearly monomorphic within a given species. Collectively, these T cells can be considered “unconventional,” in part because they recognize lipids, metabolites, and modified peptides. Unlike classical MHC-specific cells, unconventional T cells generally exhibit limited T-cell antigen receptor (TCR) repertoires and often produce innate immune cell-like rapid effector responses. Exploiting this system in new generation vaccines for human immunodeficiency virus (HIV), tuberculosis (TB), other infectious agents, and cancer was the focus of a recent workshop, “Immune Surveillance by Non-classical MHC Molecules: Improving Diversity for Antigens,” sponsored by the National Institute of Allergy and Infectious Diseases. Here, we summarize salient points presented regarding the basic immunobiology of unconventional T cells, recent advances in methodologies to measure unconventional T-cell activity in diseases, and approaches to harness their considerable clinical potential.
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spelling pubmed-63838642019-03-09 Casting a wider net: Immunosurveillance by nonclassical MHC molecules D’Souza, M. Patricia Adams, Erin Altman, John D. Birnbaum, Michael E. Boggiano, Cesar Casorati, Giulia Chien, Yueh-hsiu Conley, Anthony Eckle, Sidonia Barbara Guiomar Früh, Klaus Gondré-Lewis, Timothy Hassan, Namir Huang, Huang Jayashankar, Lakshmi Kasmar, Anne G. Kunwar, Nina Lavelle, Judith Lewinsohn, David M. Moody, Branch Picker, Louis Ramachandra, Lakshmi Shastri, Nilabh Parham, Peter McMichael, Andrew J. Yewdell, Jonathan W. PLoS Pathog Review Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition of a wide variety of nonclassical MHC molecules. These include αβ and γδ T cells that recognize different class Ib molecules (CD1, MR-1, HLA-E, G, F, et al.) that are nearly monomorphic within a given species. Collectively, these T cells can be considered “unconventional,” in part because they recognize lipids, metabolites, and modified peptides. Unlike classical MHC-specific cells, unconventional T cells generally exhibit limited T-cell antigen receptor (TCR) repertoires and often produce innate immune cell-like rapid effector responses. Exploiting this system in new generation vaccines for human immunodeficiency virus (HIV), tuberculosis (TB), other infectious agents, and cancer was the focus of a recent workshop, “Immune Surveillance by Non-classical MHC Molecules: Improving Diversity for Antigens,” sponsored by the National Institute of Allergy and Infectious Diseases. Here, we summarize salient points presented regarding the basic immunobiology of unconventional T cells, recent advances in methodologies to measure unconventional T-cell activity in diseases, and approaches to harness their considerable clinical potential. Public Library of Science 2019-02-21 /pmc/articles/PMC6383864/ /pubmed/30789961 http://dx.doi.org/10.1371/journal.ppat.1007567 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Review
D’Souza, M. Patricia
Adams, Erin
Altman, John D.
Birnbaum, Michael E.
Boggiano, Cesar
Casorati, Giulia
Chien, Yueh-hsiu
Conley, Anthony
Eckle, Sidonia Barbara Guiomar
Früh, Klaus
Gondré-Lewis, Timothy
Hassan, Namir
Huang, Huang
Jayashankar, Lakshmi
Kasmar, Anne G.
Kunwar, Nina
Lavelle, Judith
Lewinsohn, David M.
Moody, Branch
Picker, Louis
Ramachandra, Lakshmi
Shastri, Nilabh
Parham, Peter
McMichael, Andrew J.
Yewdell, Jonathan W.
Casting a wider net: Immunosurveillance by nonclassical MHC molecules
title Casting a wider net: Immunosurveillance by nonclassical MHC molecules
title_full Casting a wider net: Immunosurveillance by nonclassical MHC molecules
title_fullStr Casting a wider net: Immunosurveillance by nonclassical MHC molecules
title_full_unstemmed Casting a wider net: Immunosurveillance by nonclassical MHC molecules
title_short Casting a wider net: Immunosurveillance by nonclassical MHC molecules
title_sort casting a wider net: immunosurveillance by nonclassical mhc molecules
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383864/
https://www.ncbi.nlm.nih.gov/pubmed/30789961
http://dx.doi.org/10.1371/journal.ppat.1007567
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