Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function

Rett syndrome (RTT) is a pervasive developmental disorder caused by mutations in MECP2. Complete loss of MECP2 function in males causes congenital encephalopathy, neurodevelopmental arrest, and early lethality. Induced pluripotent stem cell (iPSC) lines from male patients harboring mutations in MECP...

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Detalles Bibliográficos
Autores principales: Kim, Jean J., Savas, Jeffrey N., Miller, Meghan T., Hu, Xindao, Carromeu, Cassiano, Lavallée-Adam, Mathieu, Freitas, Beatriz C. G., Muotri, Alysson R., Yates, John R., Ghosh, Anirvan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383942/
https://www.ncbi.nlm.nih.gov/pubmed/30789962
http://dx.doi.org/10.1371/journal.pone.0212553

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