Emergence of Colistin Resistance Gene mcr-8 and Its Variant in Raoultella ornithinolytica

Recently, a novel mobile colistin resistance gene, mcr-8, was identified in Klebsiella pneumoniae. Here, we report the identification of mcr-8 and its variant, mcr-8.4, in Raoultella ornithinolytica isolates which also belong to Enterobacteriaceae family. The mcr-8 gene was located on transferrable...

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Detalles Bibliográficos
Autores principales: Wang, Xiaoming, Wang, Yao, Zhou, Ying, Wang, Zheng, Wang, Yang, Zhang, Suxia, Shen, Zhangqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384272/
https://www.ncbi.nlm.nih.gov/pubmed/30828324
http://dx.doi.org/10.3389/fmicb.2019.00228
Descripción
Sumario:Recently, a novel mobile colistin resistance gene, mcr-8, was identified in Klebsiella pneumoniae. Here, we report the identification of mcr-8 and its variant, mcr-8.4, in Raoultella ornithinolytica isolates which also belong to Enterobacteriaceae family. The mcr-8 gene was located on transferrable plasmids with difference sizes. Notably, the transferability of mcr-8-carrying plasmids was enhanced once they entered into Escherichia coli hosts and multiple β-lactamase genes could co-transfer with mcr-8. These findings expand our knowledge of mcr-8-carrying bacterial species.

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