Emergence of Colistin Resistance Gene mcr-8 and Its Variant in Raoultella ornithinolytica

Recently, a novel mobile colistin resistance gene, mcr-8, was identified in Klebsiella pneumoniae. Here, we report the identification of mcr-8 and its variant, mcr-8.4, in Raoultella ornithinolytica isolates which also belong to Enterobacteriaceae family. The mcr-8 gene was located on transferrable...

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Autores principales: Wang, Xiaoming, Wang, Yao, Zhou, Ying, Wang, Zheng, Wang, Yang, Zhang, Suxia, Shen, Zhangqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384272/
https://www.ncbi.nlm.nih.gov/pubmed/30828324
http://dx.doi.org/10.3389/fmicb.2019.00228
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author Wang, Xiaoming
Wang, Yao
Zhou, Ying
Wang, Zheng
Wang, Yang
Zhang, Suxia
Shen, Zhangqi
author_facet Wang, Xiaoming
Wang, Yao
Zhou, Ying
Wang, Zheng
Wang, Yang
Zhang, Suxia
Shen, Zhangqi
author_sort Wang, Xiaoming
collection PubMed
description Recently, a novel mobile colistin resistance gene, mcr-8, was identified in Klebsiella pneumoniae. Here, we report the identification of mcr-8 and its variant, mcr-8.4, in Raoultella ornithinolytica isolates which also belong to Enterobacteriaceae family. The mcr-8 gene was located on transferrable plasmids with difference sizes. Notably, the transferability of mcr-8-carrying plasmids was enhanced once they entered into Escherichia coli hosts and multiple β-lactamase genes could co-transfer with mcr-8. These findings expand our knowledge of mcr-8-carrying bacterial species.
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spelling pubmed-63842722019-03-01 Emergence of Colistin Resistance Gene mcr-8 and Its Variant in Raoultella ornithinolytica Wang, Xiaoming Wang, Yao Zhou, Ying Wang, Zheng Wang, Yang Zhang, Suxia Shen, Zhangqi Front Microbiol Microbiology Recently, a novel mobile colistin resistance gene, mcr-8, was identified in Klebsiella pneumoniae. Here, we report the identification of mcr-8 and its variant, mcr-8.4, in Raoultella ornithinolytica isolates which also belong to Enterobacteriaceae family. The mcr-8 gene was located on transferrable plasmids with difference sizes. Notably, the transferability of mcr-8-carrying plasmids was enhanced once they entered into Escherichia coli hosts and multiple β-lactamase genes could co-transfer with mcr-8. These findings expand our knowledge of mcr-8-carrying bacterial species. Frontiers Media S.A. 2019-02-15 /pmc/articles/PMC6384272/ /pubmed/30828324 http://dx.doi.org/10.3389/fmicb.2019.00228 Text en Copyright © 2019 Wang, Wang, Zhou, Wang, Wang, Zhang and Shen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Wang, Xiaoming
Wang, Yao
Zhou, Ying
Wang, Zheng
Wang, Yang
Zhang, Suxia
Shen, Zhangqi
Emergence of Colistin Resistance Gene mcr-8 and Its Variant in Raoultella ornithinolytica
title Emergence of Colistin Resistance Gene mcr-8 and Its Variant in Raoultella ornithinolytica
title_full Emergence of Colistin Resistance Gene mcr-8 and Its Variant in Raoultella ornithinolytica
title_fullStr Emergence of Colistin Resistance Gene mcr-8 and Its Variant in Raoultella ornithinolytica
title_full_unstemmed Emergence of Colistin Resistance Gene mcr-8 and Its Variant in Raoultella ornithinolytica
title_short Emergence of Colistin Resistance Gene mcr-8 and Its Variant in Raoultella ornithinolytica
title_sort emergence of colistin resistance gene mcr-8 and its variant in raoultella ornithinolytica
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384272/
https://www.ncbi.nlm.nih.gov/pubmed/30828324
http://dx.doi.org/10.3389/fmicb.2019.00228
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