Ibrutinib Caused Mediastinal Emphysema and Pneumothorax in the Treatment of a Patient with Mantle Cell Lymphoma

A 70-year-old Japanese man with mantle cell lymphoma underwent extensive chemotherapy and radiation because of the relapse of mantle cell lymphoma. He developed mediastinal emphysema and a pneumothorax 14 days after treatment with 560 mg of ibrutinib. The mediastinal emphysema and the right pneumoth...

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Autores principales: Tsutsumi, Yutaka, Sekine, Takahiro, Ito, Shinichi, Matsuoka, Satomi, Teshima, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384285/
https://www.ncbi.nlm.nih.gov/pubmed/30790080
http://dx.doi.org/10.1007/s40800-019-0098-3
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author Tsutsumi, Yutaka
Sekine, Takahiro
Ito, Shinichi
Matsuoka, Satomi
Teshima, Takanori
author_facet Tsutsumi, Yutaka
Sekine, Takahiro
Ito, Shinichi
Matsuoka, Satomi
Teshima, Takanori
author_sort Tsutsumi, Yutaka
collection PubMed
description A 70-year-old Japanese man with mantle cell lymphoma underwent extensive chemotherapy and radiation because of the relapse of mantle cell lymphoma. He developed mediastinal emphysema and a pneumothorax 14 days after treatment with 560 mg of ibrutinib. The mediastinal emphysema and the right pneumothorax disappeared after the ibrutinib treatment was tapered off. The patient developed interstitial pneumonia without any infection and new lesions of mantle cell lymphoma in the lungs after restarting treatment with 560 mg of ibrutinib. In this case, the patient developed pneumonia after retreatment with ibrutinib, suggesting the small lung fibrosis that penetrated the mediastinum might have caused the emphysema and pneumothorax.
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spelling pubmed-63842852019-03-12 Ibrutinib Caused Mediastinal Emphysema and Pneumothorax in the Treatment of a Patient with Mantle Cell Lymphoma Tsutsumi, Yutaka Sekine, Takahiro Ito, Shinichi Matsuoka, Satomi Teshima, Takanori Drug Saf Case Rep Case Report A 70-year-old Japanese man with mantle cell lymphoma underwent extensive chemotherapy and radiation because of the relapse of mantle cell lymphoma. He developed mediastinal emphysema and a pneumothorax 14 days after treatment with 560 mg of ibrutinib. The mediastinal emphysema and the right pneumothorax disappeared after the ibrutinib treatment was tapered off. The patient developed interstitial pneumonia without any infection and new lesions of mantle cell lymphoma in the lungs after restarting treatment with 560 mg of ibrutinib. In this case, the patient developed pneumonia after retreatment with ibrutinib, suggesting the small lung fibrosis that penetrated the mediastinum might have caused the emphysema and pneumothorax. Springer International Publishing 2019-02-21 /pmc/articles/PMC6384285/ /pubmed/30790080 http://dx.doi.org/10.1007/s40800-019-0098-3 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
Tsutsumi, Yutaka
Sekine, Takahiro
Ito, Shinichi
Matsuoka, Satomi
Teshima, Takanori
Ibrutinib Caused Mediastinal Emphysema and Pneumothorax in the Treatment of a Patient with Mantle Cell Lymphoma
title Ibrutinib Caused Mediastinal Emphysema and Pneumothorax in the Treatment of a Patient with Mantle Cell Lymphoma
title_full Ibrutinib Caused Mediastinal Emphysema and Pneumothorax in the Treatment of a Patient with Mantle Cell Lymphoma
title_fullStr Ibrutinib Caused Mediastinal Emphysema and Pneumothorax in the Treatment of a Patient with Mantle Cell Lymphoma
title_full_unstemmed Ibrutinib Caused Mediastinal Emphysema and Pneumothorax in the Treatment of a Patient with Mantle Cell Lymphoma
title_short Ibrutinib Caused Mediastinal Emphysema and Pneumothorax in the Treatment of a Patient with Mantle Cell Lymphoma
title_sort ibrutinib caused mediastinal emphysema and pneumothorax in the treatment of a patient with mantle cell lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384285/
https://www.ncbi.nlm.nih.gov/pubmed/30790080
http://dx.doi.org/10.1007/s40800-019-0098-3
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