Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome

To our knowledge, there are no reports of status epilepticus (SE) associated with mitochondrial diseases and treated with perampanel (PER). We present three cases of patients with refractory SE associated with MELAS syndrome who responded favorably to PER. All cases were diagnosed as non-convulsive...

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Autores principales: Santamarina, Estevo, Alpuente, Alicia, Maisterra, Olga, Sueiras, María, Sarria, Silvana, Guzman, Lorena, Abraira, Laura, Salas-Puig, Javier, Toledo, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384302/
https://www.ncbi.nlm.nih.gov/pubmed/30834194
http://dx.doi.org/10.1016/j.ebcr.2019.01.008
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author Santamarina, Estevo
Alpuente, Alicia
Maisterra, Olga
Sueiras, María
Sarria, Silvana
Guzman, Lorena
Abraira, Laura
Salas-Puig, Javier
Toledo, Manuel
author_facet Santamarina, Estevo
Alpuente, Alicia
Maisterra, Olga
Sueiras, María
Sarria, Silvana
Guzman, Lorena
Abraira, Laura
Salas-Puig, Javier
Toledo, Manuel
author_sort Santamarina, Estevo
collection PubMed
description To our knowledge, there are no reports of status epilepticus (SE) associated with mitochondrial diseases and treated with perampanel (PER). We present three cases of patients with refractory SE associated with MELAS syndrome who responded favorably to PER. All cases were diagnosed as non-convulsive SE (focal without impairment of level of consciousness). After an initial treatment with other anti-seizure drugs, PER was added in all cases (8, 16 and 12 mg) and cessation of SE was observed within the next 4-8 hours. All the cases involved a stroke-like lesion present on brain MRI. In our patients, PER was an effective option in SE associated with MELAS syndrome.
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spelling pubmed-63843022019-03-04 Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome Santamarina, Estevo Alpuente, Alicia Maisterra, Olga Sueiras, María Sarria, Silvana Guzman, Lorena Abraira, Laura Salas-Puig, Javier Toledo, Manuel Epilepsy Behav Case Rep Article To our knowledge, there are no reports of status epilepticus (SE) associated with mitochondrial diseases and treated with perampanel (PER). We present three cases of patients with refractory SE associated with MELAS syndrome who responded favorably to PER. All cases were diagnosed as non-convulsive SE (focal without impairment of level of consciousness). After an initial treatment with other anti-seizure drugs, PER was added in all cases (8, 16 and 12 mg) and cessation of SE was observed within the next 4-8 hours. All the cases involved a stroke-like lesion present on brain MRI. In our patients, PER was an effective option in SE associated with MELAS syndrome. Elsevier 2019-02-07 /pmc/articles/PMC6384302/ /pubmed/30834194 http://dx.doi.org/10.1016/j.ebcr.2019.01.008 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Santamarina, Estevo
Alpuente, Alicia
Maisterra, Olga
Sueiras, María
Sarria, Silvana
Guzman, Lorena
Abraira, Laura
Salas-Puig, Javier
Toledo, Manuel
Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome
title Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome
title_full Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome
title_fullStr Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome
title_full_unstemmed Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome
title_short Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome
title_sort perampanel: a therapeutic alternative in refractory status epilepticus associated with melas syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384302/
https://www.ncbi.nlm.nih.gov/pubmed/30834194
http://dx.doi.org/10.1016/j.ebcr.2019.01.008
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