Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma()

Studies on the efficacy of small molecule inhibitors in Merkel cell carcinoma (MCC) have been limited and largely inconclusive. In this study, we investigated the therapeutic potential of a potent BET degrader, BETd-246, in the treatment of MCC. We found that MCC cell lines were significantly more s...

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Detalles Bibliográficos
Autores principales: Choi, Jae Eun, Verhaegen, Monique E., Yazdani, Sahr, Malik, Rohit, Harms, Paul W., Mangelberger, Doris, Tien, Jean, Cao, Xuhong, Wang, Yuping, Cieślik, Marcin, Gurkan, Jonathan, Yazdani, Mishaal, Jing, Xiaojun, Juckette, Kristin, Su, Fengyun, Wang, Rui, Zhou, Bing, Apel, Ingrid J., Wang, Shaomeng, Dlugosz, Andrzej A., Chinnaiyan, Arul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384317/
https://www.ncbi.nlm.nih.gov/pubmed/30797188
http://dx.doi.org/10.1016/j.neo.2019.01.003

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