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Role of diffusion-weighted magnetic resonance imaging in the differentiation of benign and malignant pulmonary lesions
PURPOSE: To evaluate the role of magnetic resonance (MRI) diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) measurement of solid and cystic pulmonary masses in differentiating benign from malignant lesions. MATERIAL AND METHODS: The study included 41 patients with pulmonary m...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384403/ https://www.ncbi.nlm.nih.gov/pubmed/30800195 http://dx.doi.org/10.5114/pjr.2018.81281 |
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author | Alnaghy, Eman Abdelaziz El-Nahas, Mahmoud Ahmed Sadek, Ahmed Galal Gwely, Noureldin Noaman Elrakhawy, Mohamed Magdy |
author_facet | Alnaghy, Eman Abdelaziz El-Nahas, Mahmoud Ahmed Sadek, Ahmed Galal Gwely, Noureldin Noaman Elrakhawy, Mohamed Magdy |
author_sort | Alnaghy, Eman Abdelaziz |
collection | PubMed |
description | PURPOSE: To evaluate the role of magnetic resonance (MRI) diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) measurement of solid and cystic pulmonary masses in differentiating benign from malignant lesions. MATERIAL AND METHODS: The study included 41 patients with pulmonary masses, who underwent conventional MRI and DWI (b value 0, 500, and 1000 s/mm²) examinations with 1.5-T MRI. The diffusion signal and the mean ADC values of the solid and cystic lesions were obtained. Statistical analyses were performed with the Mann-Whitney U test (z), Pearson’s chi-square test, and receiver operating characteristic (ROC) analysis. RESULTS: Thirty-three lesions were malignant, and eight lesions were benign. The malignant masses showed significantly higher signal intensity on DWI than benign masses (p = 0.006), and the mean ADC value of malignant solid lesions was significantly lower than that of benign lesions (p = 0.02). By ROC analysis, an ADC cut-off value of 1.4 × 10(–3) mm(2)/s was considered the threshold value, and the sensitivity and specificity were 93.8% and 75%, respectively. There was no significant difference between the ADC value of the cystic parts inside the benign and the malignant lesions. CONCLUSIONS: Diffusion-weighted MRI and measurement of ADC value can significantly differentiate between solid benign and malignant pulmonary masses. |
format | Online Article Text |
id | pubmed-6384403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-63844032019-02-22 Role of diffusion-weighted magnetic resonance imaging in the differentiation of benign and malignant pulmonary lesions Alnaghy, Eman Abdelaziz El-Nahas, Mahmoud Ahmed Sadek, Ahmed Galal Gwely, Noureldin Noaman Elrakhawy, Mohamed Magdy Pol J Radiol Original Paper PURPOSE: To evaluate the role of magnetic resonance (MRI) diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) measurement of solid and cystic pulmonary masses in differentiating benign from malignant lesions. MATERIAL AND METHODS: The study included 41 patients with pulmonary masses, who underwent conventional MRI and DWI (b value 0, 500, and 1000 s/mm²) examinations with 1.5-T MRI. The diffusion signal and the mean ADC values of the solid and cystic lesions were obtained. Statistical analyses were performed with the Mann-Whitney U test (z), Pearson’s chi-square test, and receiver operating characteristic (ROC) analysis. RESULTS: Thirty-three lesions were malignant, and eight lesions were benign. The malignant masses showed significantly higher signal intensity on DWI than benign masses (p = 0.006), and the mean ADC value of malignant solid lesions was significantly lower than that of benign lesions (p = 0.02). By ROC analysis, an ADC cut-off value of 1.4 × 10(–3) mm(2)/s was considered the threshold value, and the sensitivity and specificity were 93.8% and 75%, respectively. There was no significant difference between the ADC value of the cystic parts inside the benign and the malignant lesions. CONCLUSIONS: Diffusion-weighted MRI and measurement of ADC value can significantly differentiate between solid benign and malignant pulmonary masses. Termedia Publishing House 2018-12-20 /pmc/articles/PMC6384403/ /pubmed/30800195 http://dx.doi.org/10.5114/pjr.2018.81281 Text en Copyright © Polish Medical Society of Radiology 2018 https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0). License allowing third parties to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. |
spellingShingle | Original Paper Alnaghy, Eman Abdelaziz El-Nahas, Mahmoud Ahmed Sadek, Ahmed Galal Gwely, Noureldin Noaman Elrakhawy, Mohamed Magdy Role of diffusion-weighted magnetic resonance imaging in the differentiation of benign and malignant pulmonary lesions |
title | Role of diffusion-weighted magnetic resonance imaging in the differentiation of benign and malignant pulmonary lesions |
title_full | Role of diffusion-weighted magnetic resonance imaging in the differentiation of benign and malignant pulmonary lesions |
title_fullStr | Role of diffusion-weighted magnetic resonance imaging in the differentiation of benign and malignant pulmonary lesions |
title_full_unstemmed | Role of diffusion-weighted magnetic resonance imaging in the differentiation of benign and malignant pulmonary lesions |
title_short | Role of diffusion-weighted magnetic resonance imaging in the differentiation of benign and malignant pulmonary lesions |
title_sort | role of diffusion-weighted magnetic resonance imaging in the differentiation of benign and malignant pulmonary lesions |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384403/ https://www.ncbi.nlm.nih.gov/pubmed/30800195 http://dx.doi.org/10.5114/pjr.2018.81281 |
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