Cargando…

Role of diffusion-weighted magnetic resonance imaging in the differentiation of benign and malignant pulmonary lesions

PURPOSE: To evaluate the role of magnetic resonance (MRI) diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) measurement of solid and cystic pulmonary masses in differentiating benign from malignant lesions. MATERIAL AND METHODS: The study included 41 patients with pulmonary m...

Descripción completa

Detalles Bibliográficos
Autores principales: Alnaghy, Eman Abdelaziz, El-Nahas, Mahmoud Ahmed, Sadek, Ahmed Galal, Gwely, Noureldin Noaman, Elrakhawy, Mohamed Magdy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384403/
https://www.ncbi.nlm.nih.gov/pubmed/30800195
http://dx.doi.org/10.5114/pjr.2018.81281
_version_ 1783396978429788160
author Alnaghy, Eman Abdelaziz
El-Nahas, Mahmoud Ahmed
Sadek, Ahmed Galal
Gwely, Noureldin Noaman
Elrakhawy, Mohamed Magdy
author_facet Alnaghy, Eman Abdelaziz
El-Nahas, Mahmoud Ahmed
Sadek, Ahmed Galal
Gwely, Noureldin Noaman
Elrakhawy, Mohamed Magdy
author_sort Alnaghy, Eman Abdelaziz
collection PubMed
description PURPOSE: To evaluate the role of magnetic resonance (MRI) diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) measurement of solid and cystic pulmonary masses in differentiating benign from malignant lesions. MATERIAL AND METHODS: The study included 41 patients with pulmonary masses, who underwent conventional MRI and DWI (b value 0, 500, and 1000 s/mm²) examinations with 1.5-T MRI. The diffusion signal and the mean ADC values of the solid and cystic lesions were obtained. Statistical analyses were performed with the Mann-Whitney U test (z), Pearson’s chi-square test, and receiver operating characteristic (ROC) analysis. RESULTS: Thirty-three lesions were malignant, and eight lesions were benign. The malignant masses showed significantly higher signal intensity on DWI than benign masses (p = 0.006), and the mean ADC value of malignant solid lesions was significantly lower than that of benign lesions (p = 0.02). By ROC analysis, an ADC cut-off value of 1.4 × 10(–3) mm(2)/s was considered the threshold value, and the sensitivity and specificity were 93.8% and 75%, respectively. There was no significant difference between the ADC value of the cystic parts inside the benign and the malignant lesions. CONCLUSIONS: Diffusion-weighted MRI and measurement of ADC value can significantly differentiate between solid benign and malignant pulmonary masses.
format Online
Article
Text
id pubmed-6384403
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Termedia Publishing House
record_format MEDLINE/PubMed
spelling pubmed-63844032019-02-22 Role of diffusion-weighted magnetic resonance imaging in the differentiation of benign and malignant pulmonary lesions Alnaghy, Eman Abdelaziz El-Nahas, Mahmoud Ahmed Sadek, Ahmed Galal Gwely, Noureldin Noaman Elrakhawy, Mohamed Magdy Pol J Radiol Original Paper PURPOSE: To evaluate the role of magnetic resonance (MRI) diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) measurement of solid and cystic pulmonary masses in differentiating benign from malignant lesions. MATERIAL AND METHODS: The study included 41 patients with pulmonary masses, who underwent conventional MRI and DWI (b value 0, 500, and 1000 s/mm²) examinations with 1.5-T MRI. The diffusion signal and the mean ADC values of the solid and cystic lesions were obtained. Statistical analyses were performed with the Mann-Whitney U test (z), Pearson’s chi-square test, and receiver operating characteristic (ROC) analysis. RESULTS: Thirty-three lesions were malignant, and eight lesions were benign. The malignant masses showed significantly higher signal intensity on DWI than benign masses (p = 0.006), and the mean ADC value of malignant solid lesions was significantly lower than that of benign lesions (p = 0.02). By ROC analysis, an ADC cut-off value of 1.4 × 10(–3) mm(2)/s was considered the threshold value, and the sensitivity and specificity were 93.8% and 75%, respectively. There was no significant difference between the ADC value of the cystic parts inside the benign and the malignant lesions. CONCLUSIONS: Diffusion-weighted MRI and measurement of ADC value can significantly differentiate between solid benign and malignant pulmonary masses. Termedia Publishing House 2018-12-20 /pmc/articles/PMC6384403/ /pubmed/30800195 http://dx.doi.org/10.5114/pjr.2018.81281 Text en Copyright © Polish Medical Society of Radiology 2018 https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0). License allowing third parties to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
spellingShingle Original Paper
Alnaghy, Eman Abdelaziz
El-Nahas, Mahmoud Ahmed
Sadek, Ahmed Galal
Gwely, Noureldin Noaman
Elrakhawy, Mohamed Magdy
Role of diffusion-weighted magnetic resonance imaging in the differentiation of benign and malignant pulmonary lesions
title Role of diffusion-weighted magnetic resonance imaging in the differentiation of benign and malignant pulmonary lesions
title_full Role of diffusion-weighted magnetic resonance imaging in the differentiation of benign and malignant pulmonary lesions
title_fullStr Role of diffusion-weighted magnetic resonance imaging in the differentiation of benign and malignant pulmonary lesions
title_full_unstemmed Role of diffusion-weighted magnetic resonance imaging in the differentiation of benign and malignant pulmonary lesions
title_short Role of diffusion-weighted magnetic resonance imaging in the differentiation of benign and malignant pulmonary lesions
title_sort role of diffusion-weighted magnetic resonance imaging in the differentiation of benign and malignant pulmonary lesions
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384403/
https://www.ncbi.nlm.nih.gov/pubmed/30800195
http://dx.doi.org/10.5114/pjr.2018.81281
work_keys_str_mv AT alnaghyemanabdelaziz roleofdiffusionweightedmagneticresonanceimaginginthedifferentiationofbenignandmalignantpulmonarylesions
AT elnahasmahmoudahmed roleofdiffusionweightedmagneticresonanceimaginginthedifferentiationofbenignandmalignantpulmonarylesions
AT sadekahmedgalal roleofdiffusionweightedmagneticresonanceimaginginthedifferentiationofbenignandmalignantpulmonarylesions
AT gwelynoureldinnoaman roleofdiffusionweightedmagneticresonanceimaginginthedifferentiationofbenignandmalignantpulmonarylesions
AT elrakhawymohamedmagdy roleofdiffusionweightedmagneticresonanceimaginginthedifferentiationofbenignandmalignantpulmonarylesions