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The impact of periodontal treatment on inflammatory markers and cellular parameters associated with atherosclerosis in patients after myocardial infarction

INTRODUCTION: The aim of this study was to analyze whether periodontal treatment affects the cardiovascular risk profile of patients after myocardial infarction (MI). MATERIAL AND METHODS: The study included 30 patients with chronic periodontitis (ChP). Sociodemographic and medical variables were co...

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Autores principales: Górski, Bartłomiej, Górska, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Polish Society of Experimental and Clinical Immunology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384430/
https://www.ncbi.nlm.nih.gov/pubmed/30799993
http://dx.doi.org/10.5114/ceji.2018.81356
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author Górski, Bartłomiej
Górska, Renata
author_facet Górski, Bartłomiej
Górska, Renata
author_sort Górski, Bartłomiej
collection PubMed
description INTRODUCTION: The aim of this study was to analyze whether periodontal treatment affects the cardiovascular risk profile of patients after myocardial infarction (MI). MATERIAL AND METHODS: The study included 30 patients with chronic periodontitis (ChP). Sociodemographic and medical variables were collected. Patients were provided with scaling and root planing (SRP) 3 months after MI (1(st) visit). Periodontal examination and blood tests were performed immediately before SRP, then 1 month and 6 months after treatment (2(nd) and 3(rd) visit, respectively). RESULTS: A statistically significant decrease in blood hsCRP concentration and a decrease in the number of white blood cells (WBC) and neutrophils between the first and the second visit were observed. At 6 months after SRP, the mean platelet volume (MPV) had increased with respect to the value at 1 month after treatment. Multivariate analysis showed that the associations between: 1) change in LDL-C concentration and change in approximal plaque index value (b = –0.546, p = 0.005); 2) change in the number of monocytes and change in the plaque index value (b = 0.616, p = 0.01); 3) change in MPV and change in probing pocket depth (b = 0.567, p = 0.018) are all independent of the classic cardiovascular risk factors. CONCLUSIONS: The obtained results indicate the existence of a relationship between the state of periodontal tissues on one hand and mediators of atherosclerosis and the number of immunologically competent cells on the other hand.
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spelling pubmed-63844302019-02-22 The impact of periodontal treatment on inflammatory markers and cellular parameters associated with atherosclerosis in patients after myocardial infarction Górski, Bartłomiej Górska, Renata Cent Eur J Immunol Clinical Immunology INTRODUCTION: The aim of this study was to analyze whether periodontal treatment affects the cardiovascular risk profile of patients after myocardial infarction (MI). MATERIAL AND METHODS: The study included 30 patients with chronic periodontitis (ChP). Sociodemographic and medical variables were collected. Patients were provided with scaling and root planing (SRP) 3 months after MI (1(st) visit). Periodontal examination and blood tests were performed immediately before SRP, then 1 month and 6 months after treatment (2(nd) and 3(rd) visit, respectively). RESULTS: A statistically significant decrease in blood hsCRP concentration and a decrease in the number of white blood cells (WBC) and neutrophils between the first and the second visit were observed. At 6 months after SRP, the mean platelet volume (MPV) had increased with respect to the value at 1 month after treatment. Multivariate analysis showed that the associations between: 1) change in LDL-C concentration and change in approximal plaque index value (b = –0.546, p = 0.005); 2) change in the number of monocytes and change in the plaque index value (b = 0.616, p = 0.01); 3) change in MPV and change in probing pocket depth (b = 0.567, p = 0.018) are all independent of the classic cardiovascular risk factors. CONCLUSIONS: The obtained results indicate the existence of a relationship between the state of periodontal tissues on one hand and mediators of atherosclerosis and the number of immunologically competent cells on the other hand. Polish Society of Experimental and Clinical Immunology 2018-12-31 2018 /pmc/articles/PMC6384430/ /pubmed/30799993 http://dx.doi.org/10.5114/ceji.2018.81356 Text en Copyright: © 2018 Polish Society of Experimental and Clinical Immunology http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Immunology
Górski, Bartłomiej
Górska, Renata
The impact of periodontal treatment on inflammatory markers and cellular parameters associated with atherosclerosis in patients after myocardial infarction
title The impact of periodontal treatment on inflammatory markers and cellular parameters associated with atherosclerosis in patients after myocardial infarction
title_full The impact of periodontal treatment on inflammatory markers and cellular parameters associated with atherosclerosis in patients after myocardial infarction
title_fullStr The impact of periodontal treatment on inflammatory markers and cellular parameters associated with atherosclerosis in patients after myocardial infarction
title_full_unstemmed The impact of periodontal treatment on inflammatory markers and cellular parameters associated with atherosclerosis in patients after myocardial infarction
title_short The impact of periodontal treatment on inflammatory markers and cellular parameters associated with atherosclerosis in patients after myocardial infarction
title_sort impact of periodontal treatment on inflammatory markers and cellular parameters associated with atherosclerosis in patients after myocardial infarction
topic Clinical Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384430/
https://www.ncbi.nlm.nih.gov/pubmed/30799993
http://dx.doi.org/10.5114/ceji.2018.81356
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