Isolation of Two New Compounds and Other Constituents from Leaves of Piper crocatum and Study of Their Soluble Epoxide Hydrolase Activities

Two new phenolic glucosides, pipercroside A and B (1 and 2), along with 10 known compounds were isolated from the leaves of Piper crocatum Ruiz & Pav. Their chemical structures were elucidated through extensive spectroscopic analyses, including 1D and 2D NMR experiments and HR-ESI-MS analysis an...

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Autores principales: Li, Hong Xu, Yang, Seo Young, Kim, Young Ho, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384562/
https://www.ncbi.nlm.nih.gov/pubmed/30704047
http://dx.doi.org/10.3390/molecules24030489
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author Li, Hong Xu
Yang, Seo Young
Kim, Young Ho
Li, Wei
author_facet Li, Hong Xu
Yang, Seo Young
Kim, Young Ho
Li, Wei
author_sort Li, Hong Xu
collection PubMed
description Two new phenolic glucosides, pipercroside A and B (1 and 2), along with 10 known compounds were isolated from the leaves of Piper crocatum Ruiz & Pav. Their chemical structures were elucidated through extensive spectroscopic analyses, including 1D and 2D NMR experiments and HR-ESI-MS analysis and comparison with previously reported data. All the isolated compounds were assessed for soluble epoxide hydrolase (sEH) inhibitory activity. Among them, erigeside II (5) showed inhibitory activity with an IC(50) value of 58.5 µM.
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spelling pubmed-63845622019-02-23 Isolation of Two New Compounds and Other Constituents from Leaves of Piper crocatum and Study of Their Soluble Epoxide Hydrolase Activities Li, Hong Xu Yang, Seo Young Kim, Young Ho Li, Wei Molecules Communication Two new phenolic glucosides, pipercroside A and B (1 and 2), along with 10 known compounds were isolated from the leaves of Piper crocatum Ruiz & Pav. Their chemical structures were elucidated through extensive spectroscopic analyses, including 1D and 2D NMR experiments and HR-ESI-MS analysis and comparison with previously reported data. All the isolated compounds were assessed for soluble epoxide hydrolase (sEH) inhibitory activity. Among them, erigeside II (5) showed inhibitory activity with an IC(50) value of 58.5 µM. MDPI 2019-01-30 /pmc/articles/PMC6384562/ /pubmed/30704047 http://dx.doi.org/10.3390/molecules24030489 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Li, Hong Xu
Yang, Seo Young
Kim, Young Ho
Li, Wei
Isolation of Two New Compounds and Other Constituents from Leaves of Piper crocatum and Study of Their Soluble Epoxide Hydrolase Activities
title Isolation of Two New Compounds and Other Constituents from Leaves of Piper crocatum and Study of Their Soluble Epoxide Hydrolase Activities
title_full Isolation of Two New Compounds and Other Constituents from Leaves of Piper crocatum and Study of Their Soluble Epoxide Hydrolase Activities
title_fullStr Isolation of Two New Compounds and Other Constituents from Leaves of Piper crocatum and Study of Their Soluble Epoxide Hydrolase Activities
title_full_unstemmed Isolation of Two New Compounds and Other Constituents from Leaves of Piper crocatum and Study of Their Soluble Epoxide Hydrolase Activities
title_short Isolation of Two New Compounds and Other Constituents from Leaves of Piper crocatum and Study of Their Soluble Epoxide Hydrolase Activities
title_sort isolation of two new compounds and other constituents from leaves of piper crocatum and study of their soluble epoxide hydrolase activities
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384562/
https://www.ncbi.nlm.nih.gov/pubmed/30704047
http://dx.doi.org/10.3390/molecules24030489
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