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Drug Release Profiles and Disintegration Properties of Pectin Films
We assessed the disintegration profiles of the film dosage forms (FDs) prepared using pectin by measuring the amount of pectin dissolved from the films in a limited amount of aqueous medium. Furthermore, we used miconazole and dexamethasone as standard drugs and investigated the relationship between...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384619/ https://www.ncbi.nlm.nih.gov/pubmed/30678323 http://dx.doi.org/10.3390/ma12030355 |
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author | Murata, Yoshifumi Maida, Chieko Kofuji, Kyoko |
author_facet | Murata, Yoshifumi Maida, Chieko Kofuji, Kyoko |
author_sort | Murata, Yoshifumi |
collection | PubMed |
description | We assessed the disintegration profiles of the film dosage forms (FDs) prepared using pectin by measuring the amount of pectin dissolved from the films in a limited amount of aqueous medium. Furthermore, we used miconazole and dexamethasone as standard drugs and investigated the relationship between the disintegration rate of the FDs and the rate of drug release. We used two types of pectin in this study to develop thin films with a thickness of approximately 25–35 μm. The FDs gradually disintegrated in the aqueous medium, and the disintegration profile of the FDs differed depending on the types of pectin. In addition, the rate of disintegration of the film matrix affected the dissolution rate of the drug incorporated into the FD. Thus, our results show that FDs prepared using pectin are beneficial because of their high solubility in a limited amount of medium, and the rate of drug release from the FDs can be regulated by selecting a specific type of pectin or by altering the concentration of the film base. |
format | Online Article Text |
id | pubmed-6384619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63846192019-02-23 Drug Release Profiles and Disintegration Properties of Pectin Films Murata, Yoshifumi Maida, Chieko Kofuji, Kyoko Materials (Basel) Article We assessed the disintegration profiles of the film dosage forms (FDs) prepared using pectin by measuring the amount of pectin dissolved from the films in a limited amount of aqueous medium. Furthermore, we used miconazole and dexamethasone as standard drugs and investigated the relationship between the disintegration rate of the FDs and the rate of drug release. We used two types of pectin in this study to develop thin films with a thickness of approximately 25–35 μm. The FDs gradually disintegrated in the aqueous medium, and the disintegration profile of the FDs differed depending on the types of pectin. In addition, the rate of disintegration of the film matrix affected the dissolution rate of the drug incorporated into the FD. Thus, our results show that FDs prepared using pectin are beneficial because of their high solubility in a limited amount of medium, and the rate of drug release from the FDs can be regulated by selecting a specific type of pectin or by altering the concentration of the film base. MDPI 2019-01-24 /pmc/articles/PMC6384619/ /pubmed/30678323 http://dx.doi.org/10.3390/ma12030355 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Murata, Yoshifumi Maida, Chieko Kofuji, Kyoko Drug Release Profiles and Disintegration Properties of Pectin Films |
title | Drug Release Profiles and Disintegration Properties of Pectin Films |
title_full | Drug Release Profiles and Disintegration Properties of Pectin Films |
title_fullStr | Drug Release Profiles and Disintegration Properties of Pectin Films |
title_full_unstemmed | Drug Release Profiles and Disintegration Properties of Pectin Films |
title_short | Drug Release Profiles and Disintegration Properties of Pectin Films |
title_sort | drug release profiles and disintegration properties of pectin films |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384619/ https://www.ncbi.nlm.nih.gov/pubmed/30678323 http://dx.doi.org/10.3390/ma12030355 |
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