Iron(III)-Catalyzed Highly Regioselective Halogenation of 8-Amidoquinolines in Water

A simple protocol of iron(III)-catalyzed halogenation of 8-amidoquinolines in water under mild conditions was developed, affording the 5-halogenlated products in good to excellent yields up to 98%. The reaction mechanism most likely involves a single-electron transfer (SET) process.

Detalles Bibliográficos
Autores principales: Long, Yang, Pan, Lei, Zhou, Xiangge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384643/
https://www.ncbi.nlm.nih.gov/pubmed/30717184
http://dx.doi.org/10.3390/molecules24030535
Descripción
Sumario:A simple protocol of iron(III)-catalyzed halogenation of 8-amidoquinolines in water under mild conditions was developed, affording the 5-halogenlated products in good to excellent yields up to 98%. The reaction mechanism most likely involves a single-electron transfer (SET) process.

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