Iron(III)-Catalyzed Highly Regioselective Halogenation of 8-Amidoquinolines in Water

A simple protocol of iron(III)-catalyzed halogenation of 8-amidoquinolines in water under mild conditions was developed, affording the 5-halogenlated products in good to excellent yields up to 98%. The reaction mechanism most likely involves a single-electron transfer (SET) process.

Detalles Bibliográficos
Autores principales: Long, Yang, Pan, Lei, Zhou, Xiangge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384643/
https://www.ncbi.nlm.nih.gov/pubmed/30717184
http://dx.doi.org/10.3390/molecules24030535
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author Long, Yang
Pan, Lei
Zhou, Xiangge
author_facet Long, Yang
Pan, Lei
Zhou, Xiangge
author_sort Long, Yang
collection PubMed
description A simple protocol of iron(III)-catalyzed halogenation of 8-amidoquinolines in water under mild conditions was developed, affording the 5-halogenlated products in good to excellent yields up to 98%. The reaction mechanism most likely involves a single-electron transfer (SET) process.
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spelling pubmed-63846432019-02-23 Iron(III)-Catalyzed Highly Regioselective Halogenation of 8-Amidoquinolines in Water Long, Yang Pan, Lei Zhou, Xiangge Molecules Article A simple protocol of iron(III)-catalyzed halogenation of 8-amidoquinolines in water under mild conditions was developed, affording the 5-halogenlated products in good to excellent yields up to 98%. The reaction mechanism most likely involves a single-electron transfer (SET) process. MDPI 2019-02-01 /pmc/articles/PMC6384643/ /pubmed/30717184 http://dx.doi.org/10.3390/molecules24030535 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Long, Yang
Pan, Lei
Zhou, Xiangge
Iron(III)-Catalyzed Highly Regioselective Halogenation of 8-Amidoquinolines in Water
title Iron(III)-Catalyzed Highly Regioselective Halogenation of 8-Amidoquinolines in Water
title_full Iron(III)-Catalyzed Highly Regioselective Halogenation of 8-Amidoquinolines in Water
title_fullStr Iron(III)-Catalyzed Highly Regioselective Halogenation of 8-Amidoquinolines in Water
title_full_unstemmed Iron(III)-Catalyzed Highly Regioselective Halogenation of 8-Amidoquinolines in Water
title_short Iron(III)-Catalyzed Highly Regioselective Halogenation of 8-Amidoquinolines in Water
title_sort iron(iii)-catalyzed highly regioselective halogenation of 8-amidoquinolines in water
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384643/
https://www.ncbi.nlm.nih.gov/pubmed/30717184
http://dx.doi.org/10.3390/molecules24030535
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AT panlei ironiiicatalyzedhighlyregioselectivehalogenationof8amidoquinolinesinwater
AT zhouxiangge ironiiicatalyzedhighlyregioselectivehalogenationof8amidoquinolinesinwater

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