Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga Laurencia obtusa

Three new rare C(12) acetogenins (enyne derivatives 1–3) were isolated from the organic extract obtained from the red alga Laurencia obtusa, collected from the Red Sea. The chemical structures of the isolated compounds were established by spectroscopical data analyses. Potent anti-inflammatory effec...

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Autores principales: Alarif, Walied Mohamed, Al-Lihaibi, Sultan Semran, Bawakid, Nahed Obaid, Abdel-Lateff, Ahmed, Al-malky, Hamdan Salem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384645/
https://www.ncbi.nlm.nih.gov/pubmed/30699968
http://dx.doi.org/10.3390/molecules24030476
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author Alarif, Walied Mohamed
Al-Lihaibi, Sultan Semran
Bawakid, Nahed Obaid
Abdel-Lateff, Ahmed
Al-malky, Hamdan Salem
author_facet Alarif, Walied Mohamed
Al-Lihaibi, Sultan Semran
Bawakid, Nahed Obaid
Abdel-Lateff, Ahmed
Al-malky, Hamdan Salem
author_sort Alarif, Walied Mohamed
collection PubMed
description Three new rare C(12) acetogenins (enyne derivatives 1–3) were isolated from the organic extract obtained from the red alga Laurencia obtusa, collected from the Red Sea. The chemical structures of the isolated compounds were established by spectroscopical data analyses. Potent anti-inflammatory effect of the isolated metabolites was evidenced by inhibition of the release of inflammatory mediators (e.g., TNF-α, IL-1β and IL-6) by employing Human Peripheral Blood Mononuclear Cells (PBMC).
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spelling pubmed-63846452019-02-23 Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga Laurencia obtusa Alarif, Walied Mohamed Al-Lihaibi, Sultan Semran Bawakid, Nahed Obaid Abdel-Lateff, Ahmed Al-malky, Hamdan Salem Molecules Article Three new rare C(12) acetogenins (enyne derivatives 1–3) were isolated from the organic extract obtained from the red alga Laurencia obtusa, collected from the Red Sea. The chemical structures of the isolated compounds were established by spectroscopical data analyses. Potent anti-inflammatory effect of the isolated metabolites was evidenced by inhibition of the release of inflammatory mediators (e.g., TNF-α, IL-1β and IL-6) by employing Human Peripheral Blood Mononuclear Cells (PBMC). MDPI 2019-01-29 /pmc/articles/PMC6384645/ /pubmed/30699968 http://dx.doi.org/10.3390/molecules24030476 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alarif, Walied Mohamed
Al-Lihaibi, Sultan Semran
Bawakid, Nahed Obaid
Abdel-Lateff, Ahmed
Al-malky, Hamdan Salem
Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga Laurencia obtusa
title Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga Laurencia obtusa
title_full Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga Laurencia obtusa
title_fullStr Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga Laurencia obtusa
title_full_unstemmed Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga Laurencia obtusa
title_short Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga Laurencia obtusa
title_sort rare acetogenins with anti-inflammatory effect from the red alga laurencia obtusa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384645/
https://www.ncbi.nlm.nih.gov/pubmed/30699968
http://dx.doi.org/10.3390/molecules24030476
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