Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga Laurencia obtusa
Three new rare C(12) acetogenins (enyne derivatives 1–3) were isolated from the organic extract obtained from the red alga Laurencia obtusa, collected from the Red Sea. The chemical structures of the isolated compounds were established by spectroscopical data analyses. Potent anti-inflammatory effec...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384645/ https://www.ncbi.nlm.nih.gov/pubmed/30699968 http://dx.doi.org/10.3390/molecules24030476 |
_version_ | 1783397026194522112 |
---|---|
author | Alarif, Walied Mohamed Al-Lihaibi, Sultan Semran Bawakid, Nahed Obaid Abdel-Lateff, Ahmed Al-malky, Hamdan Salem |
author_facet | Alarif, Walied Mohamed Al-Lihaibi, Sultan Semran Bawakid, Nahed Obaid Abdel-Lateff, Ahmed Al-malky, Hamdan Salem |
author_sort | Alarif, Walied Mohamed |
collection | PubMed |
description | Three new rare C(12) acetogenins (enyne derivatives 1–3) were isolated from the organic extract obtained from the red alga Laurencia obtusa, collected from the Red Sea. The chemical structures of the isolated compounds were established by spectroscopical data analyses. Potent anti-inflammatory effect of the isolated metabolites was evidenced by inhibition of the release of inflammatory mediators (e.g., TNF-α, IL-1β and IL-6) by employing Human Peripheral Blood Mononuclear Cells (PBMC). |
format | Online Article Text |
id | pubmed-6384645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63846452019-02-23 Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga Laurencia obtusa Alarif, Walied Mohamed Al-Lihaibi, Sultan Semran Bawakid, Nahed Obaid Abdel-Lateff, Ahmed Al-malky, Hamdan Salem Molecules Article Three new rare C(12) acetogenins (enyne derivatives 1–3) were isolated from the organic extract obtained from the red alga Laurencia obtusa, collected from the Red Sea. The chemical structures of the isolated compounds were established by spectroscopical data analyses. Potent anti-inflammatory effect of the isolated metabolites was evidenced by inhibition of the release of inflammatory mediators (e.g., TNF-α, IL-1β and IL-6) by employing Human Peripheral Blood Mononuclear Cells (PBMC). MDPI 2019-01-29 /pmc/articles/PMC6384645/ /pubmed/30699968 http://dx.doi.org/10.3390/molecules24030476 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alarif, Walied Mohamed Al-Lihaibi, Sultan Semran Bawakid, Nahed Obaid Abdel-Lateff, Ahmed Al-malky, Hamdan Salem Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga Laurencia obtusa |
title | Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga Laurencia obtusa |
title_full | Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga Laurencia obtusa |
title_fullStr | Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga Laurencia obtusa |
title_full_unstemmed | Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga Laurencia obtusa |
title_short | Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga Laurencia obtusa |
title_sort | rare acetogenins with anti-inflammatory effect from the red alga laurencia obtusa |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384645/ https://www.ncbi.nlm.nih.gov/pubmed/30699968 http://dx.doi.org/10.3390/molecules24030476 |
work_keys_str_mv | AT alarifwaliedmohamed rareacetogeninswithantiinflammatoryeffectfromtheredalgalaurenciaobtusa AT allihaibisultansemran rareacetogeninswithantiinflammatoryeffectfromtheredalgalaurenciaobtusa AT bawakidnahedobaid rareacetogeninswithantiinflammatoryeffectfromtheredalgalaurenciaobtusa AT abdellateffahmed rareacetogeninswithantiinflammatoryeffectfromtheredalgalaurenciaobtusa AT almalkyhamdansalem rareacetogeninswithantiinflammatoryeffectfromtheredalgalaurenciaobtusa |