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3D Printing of Silk Fibroin for Biomedical Applications
Three-dimensional (3D) printing is regarded as a critical technological-evolution in material engineering, especially for customized biomedicine. However, a big challenge that hinders the 3D printing technique applied in biomedical field is applicable bioink. Silk fibroin (SF) is used as a biomateri...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384667/ https://www.ncbi.nlm.nih.gov/pubmed/30736388 http://dx.doi.org/10.3390/ma12030504 |
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author | Wang, Qiusheng Han, Guocong Yan, Shuqin Zhang, Qiang |
author_facet | Wang, Qiusheng Han, Guocong Yan, Shuqin Zhang, Qiang |
author_sort | Wang, Qiusheng |
collection | PubMed |
description | Three-dimensional (3D) printing is regarded as a critical technological-evolution in material engineering, especially for customized biomedicine. However, a big challenge that hinders the 3D printing technique applied in biomedical field is applicable bioink. Silk fibroin (SF) is used as a biomaterial for decades due to its remarkable high machinability and good biocompatibility and biodegradability, which provides a possible alternate of bioink for 3D printing. In this review, we summarize the requirements, characteristics and processabilities of SF bioink, in particular, focusing on the printing possibilities and capabilities of bioink. Further, the current achievements of cell-loading SF based bioinks were comprehensively viewed from their physical properties, chemical components, and bioactivities as well. Finally, the emerging issues and prospects of SF based bioink for 3D printing are given. This review provides a reference for the programmable and multiple processes and the further improvement of silk-based biomaterials fabrication by 3D printing. |
format | Online Article Text |
id | pubmed-6384667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63846672019-02-23 3D Printing of Silk Fibroin for Biomedical Applications Wang, Qiusheng Han, Guocong Yan, Shuqin Zhang, Qiang Materials (Basel) Review Three-dimensional (3D) printing is regarded as a critical technological-evolution in material engineering, especially for customized biomedicine. However, a big challenge that hinders the 3D printing technique applied in biomedical field is applicable bioink. Silk fibroin (SF) is used as a biomaterial for decades due to its remarkable high machinability and good biocompatibility and biodegradability, which provides a possible alternate of bioink for 3D printing. In this review, we summarize the requirements, characteristics and processabilities of SF bioink, in particular, focusing on the printing possibilities and capabilities of bioink. Further, the current achievements of cell-loading SF based bioinks were comprehensively viewed from their physical properties, chemical components, and bioactivities as well. Finally, the emerging issues and prospects of SF based bioink for 3D printing are given. This review provides a reference for the programmable and multiple processes and the further improvement of silk-based biomaterials fabrication by 3D printing. MDPI 2019-02-06 /pmc/articles/PMC6384667/ /pubmed/30736388 http://dx.doi.org/10.3390/ma12030504 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Qiusheng Han, Guocong Yan, Shuqin Zhang, Qiang 3D Printing of Silk Fibroin for Biomedical Applications |
title | 3D Printing of Silk Fibroin for Biomedical Applications |
title_full | 3D Printing of Silk Fibroin for Biomedical Applications |
title_fullStr | 3D Printing of Silk Fibroin for Biomedical Applications |
title_full_unstemmed | 3D Printing of Silk Fibroin for Biomedical Applications |
title_short | 3D Printing of Silk Fibroin for Biomedical Applications |
title_sort | 3d printing of silk fibroin for biomedical applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384667/ https://www.ncbi.nlm.nih.gov/pubmed/30736388 http://dx.doi.org/10.3390/ma12030504 |
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