Cargando…

3D Printing of Silk Fibroin for Biomedical Applications

Three-dimensional (3D) printing is regarded as a critical technological-evolution in material engineering, especially for customized biomedicine. However, a big challenge that hinders the 3D printing technique applied in biomedical field is applicable bioink. Silk fibroin (SF) is used as a biomateri...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Qiusheng, Han, Guocong, Yan, Shuqin, Zhang, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384667/
https://www.ncbi.nlm.nih.gov/pubmed/30736388
http://dx.doi.org/10.3390/ma12030504
_version_ 1783397031397556224
author Wang, Qiusheng
Han, Guocong
Yan, Shuqin
Zhang, Qiang
author_facet Wang, Qiusheng
Han, Guocong
Yan, Shuqin
Zhang, Qiang
author_sort Wang, Qiusheng
collection PubMed
description Three-dimensional (3D) printing is regarded as a critical technological-evolution in material engineering, especially for customized biomedicine. However, a big challenge that hinders the 3D printing technique applied in biomedical field is applicable bioink. Silk fibroin (SF) is used as a biomaterial for decades due to its remarkable high machinability and good biocompatibility and biodegradability, which provides a possible alternate of bioink for 3D printing. In this review, we summarize the requirements, characteristics and processabilities of SF bioink, in particular, focusing on the printing possibilities and capabilities of bioink. Further, the current achievements of cell-loading SF based bioinks were comprehensively viewed from their physical properties, chemical components, and bioactivities as well. Finally, the emerging issues and prospects of SF based bioink for 3D printing are given. This review provides a reference for the programmable and multiple processes and the further improvement of silk-based biomaterials fabrication by 3D printing.
format Online
Article
Text
id pubmed-6384667
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-63846672019-02-23 3D Printing of Silk Fibroin for Biomedical Applications Wang, Qiusheng Han, Guocong Yan, Shuqin Zhang, Qiang Materials (Basel) Review Three-dimensional (3D) printing is regarded as a critical technological-evolution in material engineering, especially for customized biomedicine. However, a big challenge that hinders the 3D printing technique applied in biomedical field is applicable bioink. Silk fibroin (SF) is used as a biomaterial for decades due to its remarkable high machinability and good biocompatibility and biodegradability, which provides a possible alternate of bioink for 3D printing. In this review, we summarize the requirements, characteristics and processabilities of SF bioink, in particular, focusing on the printing possibilities and capabilities of bioink. Further, the current achievements of cell-loading SF based bioinks were comprehensively viewed from their physical properties, chemical components, and bioactivities as well. Finally, the emerging issues and prospects of SF based bioink for 3D printing are given. This review provides a reference for the programmable and multiple processes and the further improvement of silk-based biomaterials fabrication by 3D printing. MDPI 2019-02-06 /pmc/articles/PMC6384667/ /pubmed/30736388 http://dx.doi.org/10.3390/ma12030504 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Qiusheng
Han, Guocong
Yan, Shuqin
Zhang, Qiang
3D Printing of Silk Fibroin for Biomedical Applications
title 3D Printing of Silk Fibroin for Biomedical Applications
title_full 3D Printing of Silk Fibroin for Biomedical Applications
title_fullStr 3D Printing of Silk Fibroin for Biomedical Applications
title_full_unstemmed 3D Printing of Silk Fibroin for Biomedical Applications
title_short 3D Printing of Silk Fibroin for Biomedical Applications
title_sort 3d printing of silk fibroin for biomedical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384667/
https://www.ncbi.nlm.nih.gov/pubmed/30736388
http://dx.doi.org/10.3390/ma12030504
work_keys_str_mv AT wangqiusheng 3dprintingofsilkfibroinforbiomedicalapplications
AT hanguocong 3dprintingofsilkfibroinforbiomedicalapplications
AT yanshuqin 3dprintingofsilkfibroinforbiomedicalapplications
AT zhangqiang 3dprintingofsilkfibroinforbiomedicalapplications