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One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery
The development of various magnetically-responsive nanostructures is of great importance in biomedicine. The controlled assembly of many small superparamagnetic nanocrystals into large multi-core clusters is needed for effective magnetic drug delivery. Here, we present a novel one-pot method for the...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384742/ https://www.ncbi.nlm.nih.gov/pubmed/30759725 http://dx.doi.org/10.3390/ma12030540 |
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author | Dragar, Črt Potrč, Tanja Nemec, Sebastjan Roškar, Robert Pajk, Stane Kocbek, Petra Kralj, Slavko |
author_facet | Dragar, Črt Potrč, Tanja Nemec, Sebastjan Roškar, Robert Pajk, Stane Kocbek, Petra Kralj, Slavko |
author_sort | Dragar, Črt |
collection | PubMed |
description | The development of various magnetically-responsive nanostructures is of great importance in biomedicine. The controlled assembly of many small superparamagnetic nanocrystals into large multi-core clusters is needed for effective magnetic drug delivery. Here, we present a novel one-pot method for the preparation of multi-core clusters for drug delivery (i.e., magnetic nanocarriers). The method is based on hot homogenization of a hydrophobic phase containing a nonpolar surfactant into an aqueous phase, using ultrasonication. The solvent-free hydrophobic phase that contained tetradecan-1-ol, γ-Fe(2)O(3) nanocrystals, orlistat, and surfactant was dispersed into a warm aqueous surfactant solution, with the formation of small droplets. Then, a pre-cooled aqueous phase was added for rapid cooling and the formation of solid magnetic nanocarriers. Two different nonpolar surfactants, polyethylene glycol dodecyl ether (B4) and our own N(1),N(1)-dimethyl-N(2)-(tricosan-12-yl)ethane-1,2-diamine (SP11), were investigated for the preparation of MC-B4 and MC-SP11 magnetic nanocarriers, respectively. The nanocarriers formed were of spherical shape, with mean hydrodynamic sizes <160 nm, good colloidal stability, and high drug loading (7.65 wt.%). The MC-B4 nanocarriers showed prolonged drug release, while no drug release was seen for the MC-SP11 nanocarriers over the same time frame. Thus, the selection of a nonpolar surfactant for preparation of magnetic nanocarriers is crucial to enable drug release from nanocarrier. |
format | Online Article Text |
id | pubmed-6384742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63847422019-02-23 One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery Dragar, Črt Potrč, Tanja Nemec, Sebastjan Roškar, Robert Pajk, Stane Kocbek, Petra Kralj, Slavko Materials (Basel) Article The development of various magnetically-responsive nanostructures is of great importance in biomedicine. The controlled assembly of many small superparamagnetic nanocrystals into large multi-core clusters is needed for effective magnetic drug delivery. Here, we present a novel one-pot method for the preparation of multi-core clusters for drug delivery (i.e., magnetic nanocarriers). The method is based on hot homogenization of a hydrophobic phase containing a nonpolar surfactant into an aqueous phase, using ultrasonication. The solvent-free hydrophobic phase that contained tetradecan-1-ol, γ-Fe(2)O(3) nanocrystals, orlistat, and surfactant was dispersed into a warm aqueous surfactant solution, with the formation of small droplets. Then, a pre-cooled aqueous phase was added for rapid cooling and the formation of solid magnetic nanocarriers. Two different nonpolar surfactants, polyethylene glycol dodecyl ether (B4) and our own N(1),N(1)-dimethyl-N(2)-(tricosan-12-yl)ethane-1,2-diamine (SP11), were investigated for the preparation of MC-B4 and MC-SP11 magnetic nanocarriers, respectively. The nanocarriers formed were of spherical shape, with mean hydrodynamic sizes <160 nm, good colloidal stability, and high drug loading (7.65 wt.%). The MC-B4 nanocarriers showed prolonged drug release, while no drug release was seen for the MC-SP11 nanocarriers over the same time frame. Thus, the selection of a nonpolar surfactant for preparation of magnetic nanocarriers is crucial to enable drug release from nanocarrier. MDPI 2019-02-12 /pmc/articles/PMC6384742/ /pubmed/30759725 http://dx.doi.org/10.3390/ma12030540 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dragar, Črt Potrč, Tanja Nemec, Sebastjan Roškar, Robert Pajk, Stane Kocbek, Petra Kralj, Slavko One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery |
title | One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery |
title_full | One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery |
title_fullStr | One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery |
title_full_unstemmed | One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery |
title_short | One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery |
title_sort | one-pot method for preparation of magnetic multi-core nanocarriers for drug delivery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384742/ https://www.ncbi.nlm.nih.gov/pubmed/30759725 http://dx.doi.org/10.3390/ma12030540 |
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