Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System

Magnetic Nanoparticles (MNPs) are of great interest in biomedicine, due to their wide range of applications. During recent years, one of the most challenging goals is the development of new strategies to finely tune the unique properties of MNPs, in order to improve their effectiveness in the biomed...

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Autores principales: Ansari, Shoeb Anwar Mohammed Khawja, Ficiarà, Eleonora, Ruffinatti, Federico Alessandro, Stura, Ilaria, Argenziano, Monica, Abollino, Ornella, Cavalli, Roberta, Guiot, Caterina, D’Agata, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384775/
https://www.ncbi.nlm.nih.gov/pubmed/30717431
http://dx.doi.org/10.3390/ma12030465
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author Ansari, Shoeb Anwar Mohammed Khawja
Ficiarà, Eleonora
Ruffinatti, Federico Alessandro
Stura, Ilaria
Argenziano, Monica
Abollino, Ornella
Cavalli, Roberta
Guiot, Caterina
D’Agata, Federico
author_facet Ansari, Shoeb Anwar Mohammed Khawja
Ficiarà, Eleonora
Ruffinatti, Federico Alessandro
Stura, Ilaria
Argenziano, Monica
Abollino, Ornella
Cavalli, Roberta
Guiot, Caterina
D’Agata, Federico
author_sort Ansari, Shoeb Anwar Mohammed Khawja
collection PubMed
description Magnetic Nanoparticles (MNPs) are of great interest in biomedicine, due to their wide range of applications. During recent years, one of the most challenging goals is the development of new strategies to finely tune the unique properties of MNPs, in order to improve their effectiveness in the biomedical field. This review provides an up-to-date overview of the methods of synthesis and functionalization of MNPs focusing on Iron Oxide Nanoparticles (IONPs). Firstly, synthesis strategies for fabricating IONPs of different composition, sizes, shapes, and structures are outlined. We describe the close link between physicochemical properties and magnetic characterization, essential to developing innovative and powerful magnetic-driven nanocarriers. In conclusion, we provide a complete background of IONPs functionalization, safety, and applications for the treatment of Central Nervous System disorders.
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spelling pubmed-63847752019-02-23 Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System Ansari, Shoeb Anwar Mohammed Khawja Ficiarà, Eleonora Ruffinatti, Federico Alessandro Stura, Ilaria Argenziano, Monica Abollino, Ornella Cavalli, Roberta Guiot, Caterina D’Agata, Federico Materials (Basel) Review Magnetic Nanoparticles (MNPs) are of great interest in biomedicine, due to their wide range of applications. During recent years, one of the most challenging goals is the development of new strategies to finely tune the unique properties of MNPs, in order to improve their effectiveness in the biomedical field. This review provides an up-to-date overview of the methods of synthesis and functionalization of MNPs focusing on Iron Oxide Nanoparticles (IONPs). Firstly, synthesis strategies for fabricating IONPs of different composition, sizes, shapes, and structures are outlined. We describe the close link between physicochemical properties and magnetic characterization, essential to developing innovative and powerful magnetic-driven nanocarriers. In conclusion, we provide a complete background of IONPs functionalization, safety, and applications for the treatment of Central Nervous System disorders. MDPI 2019-02-02 /pmc/articles/PMC6384775/ /pubmed/30717431 http://dx.doi.org/10.3390/ma12030465 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ansari, Shoeb Anwar Mohammed Khawja
Ficiarà, Eleonora
Ruffinatti, Federico Alessandro
Stura, Ilaria
Argenziano, Monica
Abollino, Ornella
Cavalli, Roberta
Guiot, Caterina
D’Agata, Federico
Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System
title Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System
title_full Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System
title_fullStr Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System
title_full_unstemmed Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System
title_short Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System
title_sort magnetic iron oxide nanoparticles: synthesis, characterization and functionalization for biomedical applications in the central nervous system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384775/
https://www.ncbi.nlm.nih.gov/pubmed/30717431
http://dx.doi.org/10.3390/ma12030465
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