New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities

Three previously undescribed iridoids, cornusfurals A–C, were isolated from the ethanolic extracts of fruits of Cornus officinalis. Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared...

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Detalles Bibliográficos
Autores principales: Ji, Lin-lin, Wang, Xin, Li, Jin-jie, Zhong, Xiang-jian, Zhang, Bo, Juan, Jing, Shang, Xiao-ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384786/
https://www.ncbi.nlm.nih.gov/pubmed/30754635
http://dx.doi.org/10.3390/molecules24030625
Descripción
Sumario:Three previously undescribed iridoids, cornusfurals A–C, were isolated from the ethanolic extracts of fruits of Cornus officinalis. Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared spectroscopy, and mass spectrometry. The neuroprotective activity was evaluated by measuring corticosterone-induced damage in PC12 cells. The results showed that cornusfural B decreased corticosterone-induced PC12 cell damage compared with that in model cells.

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