New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities

Three previously undescribed iridoids, cornusfurals A–C, were isolated from the ethanolic extracts of fruits of Cornus officinalis. Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared...

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Autores principales: Ji, Lin-lin, Wang, Xin, Li, Jin-jie, Zhong, Xiang-jian, Zhang, Bo, Juan, Jing, Shang, Xiao-ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384786/
https://www.ncbi.nlm.nih.gov/pubmed/30754635
http://dx.doi.org/10.3390/molecules24030625
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author Ji, Lin-lin
Wang, Xin
Li, Jin-jie
Zhong, Xiang-jian
Zhang, Bo
Juan, Jing
Shang, Xiao-ya
author_facet Ji, Lin-lin
Wang, Xin
Li, Jin-jie
Zhong, Xiang-jian
Zhang, Bo
Juan, Jing
Shang, Xiao-ya
author_sort Ji, Lin-lin
collection PubMed
description Three previously undescribed iridoids, cornusfurals A–C, were isolated from the ethanolic extracts of fruits of Cornus officinalis. Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared spectroscopy, and mass spectrometry. The neuroprotective activity was evaluated by measuring corticosterone-induced damage in PC12 cells. The results showed that cornusfural B decreased corticosterone-induced PC12 cell damage compared with that in model cells.
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spelling pubmed-63847862019-02-23 New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities Ji, Lin-lin Wang, Xin Li, Jin-jie Zhong, Xiang-jian Zhang, Bo Juan, Jing Shang, Xiao-ya Molecules Article Three previously undescribed iridoids, cornusfurals A–C, were isolated from the ethanolic extracts of fruits of Cornus officinalis. Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared spectroscopy, and mass spectrometry. The neuroprotective activity was evaluated by measuring corticosterone-induced damage in PC12 cells. The results showed that cornusfural B decreased corticosterone-induced PC12 cell damage compared with that in model cells. MDPI 2019-02-11 /pmc/articles/PMC6384786/ /pubmed/30754635 http://dx.doi.org/10.3390/molecules24030625 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ji, Lin-lin
Wang, Xin
Li, Jin-jie
Zhong, Xiang-jian
Zhang, Bo
Juan, Jing
Shang, Xiao-ya
New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities
title New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities
title_full New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities
title_fullStr New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities
title_full_unstemmed New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities
title_short New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities
title_sort new iridoid derivatives from the fruits of cornus officinalis and their neuroprotective activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384786/
https://www.ncbi.nlm.nih.gov/pubmed/30754635
http://dx.doi.org/10.3390/molecules24030625
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