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Theaflavins Improve Memory Impairment and Depression-Like Behavior by Regulating Microglial Activation

Inflammation in the brain is associated with various disorders including Alzheimer’s disease and depression. Thus, inflammation has received increasing attention regarding preventive approaches to such disorders. Epidemiological investigations have reported that drinking tea reduces the risk of deme...

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Autores principales: Ano, Yasuhisa, Ohya, Rena, Kita, Masahiro, Taniguchi, Yoshimasa, Kondo, Keiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384870/
https://www.ncbi.nlm.nih.gov/pubmed/30696093
http://dx.doi.org/10.3390/molecules24030467
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author Ano, Yasuhisa
Ohya, Rena
Kita, Masahiro
Taniguchi, Yoshimasa
Kondo, Keiji
author_facet Ano, Yasuhisa
Ohya, Rena
Kita, Masahiro
Taniguchi, Yoshimasa
Kondo, Keiji
author_sort Ano, Yasuhisa
collection PubMed
description Inflammation in the brain is associated with various disorders including Alzheimer’s disease and depression. Thus, inflammation has received increasing attention regarding preventive approaches to such disorders. Epidemiological investigations have reported that drinking tea reduces the risk of dementia and depression. Theaflavins, a polyphenol found in black tea, are known to have anti-oxidative and anti-inflammation effects, but the effects of theaflavins on cognitive decline and depression induced by inflammation have not been investigated. To address this research gap, the present study assessed whether theaflavins could protect synapses and dendrites damaged by inflammation and prevent concomitant memory impairment and depression-like behavior in mice. Intracerebroventricular injection with lipopolysaccharide (LPS) induces neural inflammation associated with reduced spontaneous alternations in the Y-maze test and increased immobility in the tail suspension test, indicating impaired spatial memory and depression-like behavior, respectively. Oral administration with theaflavins prevented these behavioral changes induced by LPS. Theaflavins also suppressed productions of inflammatory cytokines and prevented dendritic atrophy and spine loss in the brain. Notably, theaflavins have a stronger anti-inflammatory effect than other polyphenols such as catechin, chlorogenic acid, and caffeic acid. These results suggest that theaflavins can suppress neural inflammation and prevent the symptoms of inflammation-related brain disorders.
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spelling pubmed-63848702019-02-23 Theaflavins Improve Memory Impairment and Depression-Like Behavior by Regulating Microglial Activation Ano, Yasuhisa Ohya, Rena Kita, Masahiro Taniguchi, Yoshimasa Kondo, Keiji Molecules Article Inflammation in the brain is associated with various disorders including Alzheimer’s disease and depression. Thus, inflammation has received increasing attention regarding preventive approaches to such disorders. Epidemiological investigations have reported that drinking tea reduces the risk of dementia and depression. Theaflavins, a polyphenol found in black tea, are known to have anti-oxidative and anti-inflammation effects, but the effects of theaflavins on cognitive decline and depression induced by inflammation have not been investigated. To address this research gap, the present study assessed whether theaflavins could protect synapses and dendrites damaged by inflammation and prevent concomitant memory impairment and depression-like behavior in mice. Intracerebroventricular injection with lipopolysaccharide (LPS) induces neural inflammation associated with reduced spontaneous alternations in the Y-maze test and increased immobility in the tail suspension test, indicating impaired spatial memory and depression-like behavior, respectively. Oral administration with theaflavins prevented these behavioral changes induced by LPS. Theaflavins also suppressed productions of inflammatory cytokines and prevented dendritic atrophy and spine loss in the brain. Notably, theaflavins have a stronger anti-inflammatory effect than other polyphenols such as catechin, chlorogenic acid, and caffeic acid. These results suggest that theaflavins can suppress neural inflammation and prevent the symptoms of inflammation-related brain disorders. MDPI 2019-01-28 /pmc/articles/PMC6384870/ /pubmed/30696093 http://dx.doi.org/10.3390/molecules24030467 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ano, Yasuhisa
Ohya, Rena
Kita, Masahiro
Taniguchi, Yoshimasa
Kondo, Keiji
Theaflavins Improve Memory Impairment and Depression-Like Behavior by Regulating Microglial Activation
title Theaflavins Improve Memory Impairment and Depression-Like Behavior by Regulating Microglial Activation
title_full Theaflavins Improve Memory Impairment and Depression-Like Behavior by Regulating Microglial Activation
title_fullStr Theaflavins Improve Memory Impairment and Depression-Like Behavior by Regulating Microglial Activation
title_full_unstemmed Theaflavins Improve Memory Impairment and Depression-Like Behavior by Regulating Microglial Activation
title_short Theaflavins Improve Memory Impairment and Depression-Like Behavior by Regulating Microglial Activation
title_sort theaflavins improve memory impairment and depression-like behavior by regulating microglial activation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384870/
https://www.ncbi.nlm.nih.gov/pubmed/30696093
http://dx.doi.org/10.3390/molecules24030467
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