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Optimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates

Antibody-drug conjugates (ADCs) are promising therapies for haematological cancers. Historically, their therapeutic benefit is due to ADC targeting of lineage-restricted antigens. The C-X-C motif chemokine receptor 4 (CXCR4) is attractive for targeted therapy of haematological cancers, given its exp...

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Detalles Bibliográficos
Autores principales:	Costa, Maria José, Kudaravalli, Jyothirmayee, Ma, Jing-Tyan, Ho, Wei-Hsien, Delaria, Kathy, Holz, Charles, Stauffer, Angela, Chunyk, Allison Given, Zong, Qing, Blasi, Eileen, Buetow, Bernard, Tran, Thomas-Toan, Lindquist, Kevin, Dorywalska, Magdalena, Rajpal, Arvind, Shelton, David L., Strop, Pavel, Liu, Shu-Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384886/ https://www.ncbi.nlm.nih.gov/pubmed/30792442 http://dx.doi.org/10.1038/s41598-019-38745-x

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