Cyclic Peptide-Based Sirtuin Substrates

In the current study, four side chain-to-side chain cyclic peptides (three 5-mers and one 4-mer) harboring N(ε)-acetyl-lysine or N(ε)-myristoyl-lysine were found to be in vitro substrates of the human SIRT1/2/3-catalyzed deacylation with good substrate activities, as judged by the k(cat)/K(M) ratios...

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Detalles Bibliográficos
Autores principales: Chen, Di, Yan, Lingling, Zheng, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384901/
https://www.ncbi.nlm.nih.gov/pubmed/30682801
http://dx.doi.org/10.3390/molecules24030424
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author Chen, Di
Yan, Lingling
Zheng, Weiping
author_facet Chen, Di
Yan, Lingling
Zheng, Weiping
author_sort Chen, Di
collection PubMed
description In the current study, four side chain-to-side chain cyclic peptides (three 5-mers and one 4-mer) harboring N(ε)-acetyl-lysine or N(ε)-myristoyl-lysine were found to be in vitro substrates of the human SIRT1/2/3-catalyzed deacylation with good substrate activities, as judged by the k(cat)/K(M) ratios.
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spelling pubmed-63849012019-02-23 Cyclic Peptide-Based Sirtuin Substrates Chen, Di Yan, Lingling Zheng, Weiping Molecules Communication In the current study, four side chain-to-side chain cyclic peptides (three 5-mers and one 4-mer) harboring N(ε)-acetyl-lysine or N(ε)-myristoyl-lysine were found to be in vitro substrates of the human SIRT1/2/3-catalyzed deacylation with good substrate activities, as judged by the k(cat)/K(M) ratios. MDPI 2019-01-24 /pmc/articles/PMC6384901/ /pubmed/30682801 http://dx.doi.org/10.3390/molecules24030424 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Chen, Di
Yan, Lingling
Zheng, Weiping
Cyclic Peptide-Based Sirtuin Substrates
title Cyclic Peptide-Based Sirtuin Substrates
title_full Cyclic Peptide-Based Sirtuin Substrates
title_fullStr Cyclic Peptide-Based Sirtuin Substrates
title_full_unstemmed Cyclic Peptide-Based Sirtuin Substrates
title_short Cyclic Peptide-Based Sirtuin Substrates
title_sort cyclic peptide-based sirtuin substrates
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384901/
https://www.ncbi.nlm.nih.gov/pubmed/30682801
http://dx.doi.org/10.3390/molecules24030424
work_keys_str_mv AT chendi cyclicpeptidebasedsirtuinsubstrates
AT yanlingling cyclicpeptidebasedsirtuinsubstrates
AT zhengweiping cyclicpeptidebasedsirtuinsubstrates

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