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Cyclic Peptide-Based Sirtuin Substrates
In the current study, four side chain-to-side chain cyclic peptides (three 5-mers and one 4-mer) harboring N(ε)-acetyl-lysine or N(ε)-myristoyl-lysine were found to be in vitro substrates of the human SIRT1/2/3-catalyzed deacylation with good substrate activities, as judged by the k(cat)/K(M) ratios...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384901/ https://www.ncbi.nlm.nih.gov/pubmed/30682801 http://dx.doi.org/10.3390/molecules24030424 |