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The shape of human squalene epoxidase expands the arsenal against cancer

Squalene epoxidase (also known as squalene monooxygenase, EC 1.14.99.7) is a key rate-limiting enzyme in cholesterol biosynthesis. Anil Padyana and colleagues report the long awaited structure of human squalene epoxidase (SQLE). They solved the crystal structure of the catalytic domain of human SQLE...

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Detalles Bibliográficos
Autores principales:	Brown, Andrew J., Chua, Ngee Kiat, Yan, Nieng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Comment
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384927/ https://www.ncbi.nlm.nih.gov/pubmed/30792392 http://dx.doi.org/10.1038/s41467-019-08866-y

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