Cucurbitacin B Induces the Lysosomal Degradation of EGFR and Suppresses the CIP2A/PP2A/Akt Signaling Axis in Gefitinib-Resistant Non-Small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) patients carrying an epidermal growth factor receptor (EGFR) mutation are initially sensitive to EGFR-tyrosine kinase inhibitors (TKIs) treatment, but soon develop an acquired resistance. The treatment effect of EGFR-TKIs-resistant NSCLC patients still faces challe...

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Detalles Bibliográficos
Autores principales: Liu, Pengfei, Xiang, Yuchen, Liu, Xuewen, Zhang, Te, Yang, Rui, Chen, Sen, Xu, Li, Yu, Qingqing, Zhao, Huzi, Zhang, Liang, Liu, Ying, Si, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384961/
https://www.ncbi.nlm.nih.gov/pubmed/30759826
http://dx.doi.org/10.3390/molecules24030647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384961/
https://www.ncbi.nlm.nih.gov/pubmed/30759826
http://dx.doi.org/10.3390/molecules24030647

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