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Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids

[Image: see text] A recently discovered photodecarboxylase from Chlorella variabilis NC64A (CvFAP) bears the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids. CvFAP, however, exhibits a clear preference for long-chain fatty acids thereby limiting its broad appl...

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Detalles Bibliográficos
Autores principales: Zhang, Wuyuan, Ma, Ming, Huijbers, Mieke M. E., Filonenko, Georgy A., Pidko, Evgeny A., van Schie, Morten, de Boer, Sabrina, Burek, Bastien O., Bloh, Jonathan Z., van Berkel, Willem J. H., Smith, Wilson A., Hollmann, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385076/
https://www.ncbi.nlm.nih.gov/pubmed/30673222
http://dx.doi.org/10.1021/jacs.8b12282
Descripción
Sumario:[Image: see text] A recently discovered photodecarboxylase from Chlorella variabilis NC64A (CvFAP) bears the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids. CvFAP, however, exhibits a clear preference for long-chain fatty acids thereby limiting its broad applicability. In this contribution, we demonstrate that the decoy molecule approach enables conversion of a broad range of carboxylic acids by filling up the vacant substrate access channel of the photodecarboxylase. These results not only demonstrate a practical application of a unique, photoactivated enzyme but also pave the way to selective production of short-chain alkanes from waste carboxylic acids under mild reaction conditions.