Cargando…
Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids
[Image: see text] A recently discovered photodecarboxylase from Chlorella variabilis NC64A (CvFAP) bears the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids. CvFAP, however, exhibits a clear preference for long-chain fatty acids thereby limiting its broad appl...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2019
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385076/ https://www.ncbi.nlm.nih.gov/pubmed/30673222 http://dx.doi.org/10.1021/jacs.8b12282 |
_version_ | 1783397121912733696 |
---|---|
author | Zhang, Wuyuan Ma, Ming Huijbers, Mieke M. E. Filonenko, Georgy A. Pidko, Evgeny A. van Schie, Morten de Boer, Sabrina Burek, Bastien O. Bloh, Jonathan Z. van Berkel, Willem J. H. Smith, Wilson A. Hollmann, Frank |
author_facet | Zhang, Wuyuan Ma, Ming Huijbers, Mieke M. E. Filonenko, Georgy A. Pidko, Evgeny A. van Schie, Morten de Boer, Sabrina Burek, Bastien O. Bloh, Jonathan Z. van Berkel, Willem J. H. Smith, Wilson A. Hollmann, Frank |
author_sort | Zhang, Wuyuan |
collection | PubMed |
description | [Image: see text] A recently discovered photodecarboxylase from Chlorella variabilis NC64A (CvFAP) bears the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids. CvFAP, however, exhibits a clear preference for long-chain fatty acids thereby limiting its broad applicability. In this contribution, we demonstrate that the decoy molecule approach enables conversion of a broad range of carboxylic acids by filling up the vacant substrate access channel of the photodecarboxylase. These results not only demonstrate a practical application of a unique, photoactivated enzyme but also pave the way to selective production of short-chain alkanes from waste carboxylic acids under mild reaction conditions. |
format | Online Article Text |
id | pubmed-6385076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | American Chemical
Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-63850762019-02-23 Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids Zhang, Wuyuan Ma, Ming Huijbers, Mieke M. E. Filonenko, Georgy A. Pidko, Evgeny A. van Schie, Morten de Boer, Sabrina Burek, Bastien O. Bloh, Jonathan Z. van Berkel, Willem J. H. Smith, Wilson A. Hollmann, Frank J Am Chem Soc [Image: see text] A recently discovered photodecarboxylase from Chlorella variabilis NC64A (CvFAP) bears the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids. CvFAP, however, exhibits a clear preference for long-chain fatty acids thereby limiting its broad applicability. In this contribution, we demonstrate that the decoy molecule approach enables conversion of a broad range of carboxylic acids by filling up the vacant substrate access channel of the photodecarboxylase. These results not only demonstrate a practical application of a unique, photoactivated enzyme but also pave the way to selective production of short-chain alkanes from waste carboxylic acids under mild reaction conditions. American Chemical Society 2019-01-23 2019-02-20 /pmc/articles/PMC6385076/ /pubmed/30673222 http://dx.doi.org/10.1021/jacs.8b12282 Text en Copyright © 2019 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes. |
spellingShingle | Zhang, Wuyuan Ma, Ming Huijbers, Mieke M. E. Filonenko, Georgy A. Pidko, Evgeny A. van Schie, Morten de Boer, Sabrina Burek, Bastien O. Bloh, Jonathan Z. van Berkel, Willem J. H. Smith, Wilson A. Hollmann, Frank Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids |
title | Hydrocarbon
Synthesis via Photoenzymatic Decarboxylation
of Carboxylic Acids |
title_full | Hydrocarbon
Synthesis via Photoenzymatic Decarboxylation
of Carboxylic Acids |
title_fullStr | Hydrocarbon
Synthesis via Photoenzymatic Decarboxylation
of Carboxylic Acids |
title_full_unstemmed | Hydrocarbon
Synthesis via Photoenzymatic Decarboxylation
of Carboxylic Acids |
title_short | Hydrocarbon
Synthesis via Photoenzymatic Decarboxylation
of Carboxylic Acids |
title_sort | hydrocarbon
synthesis via photoenzymatic decarboxylation
of carboxylic acids |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385076/ https://www.ncbi.nlm.nih.gov/pubmed/30673222 http://dx.doi.org/10.1021/jacs.8b12282 |
work_keys_str_mv | AT zhangwuyuan hydrocarbonsynthesisviaphotoenzymaticdecarboxylationofcarboxylicacids AT maming hydrocarbonsynthesisviaphotoenzymaticdecarboxylationofcarboxylicacids AT huijbersmiekeme hydrocarbonsynthesisviaphotoenzymaticdecarboxylationofcarboxylicacids AT filonenkogeorgya hydrocarbonsynthesisviaphotoenzymaticdecarboxylationofcarboxylicacids AT pidkoevgenya hydrocarbonsynthesisviaphotoenzymaticdecarboxylationofcarboxylicacids AT vanschiemorten hydrocarbonsynthesisviaphotoenzymaticdecarboxylationofcarboxylicacids AT deboersabrina hydrocarbonsynthesisviaphotoenzymaticdecarboxylationofcarboxylicacids AT burekbastieno hydrocarbonsynthesisviaphotoenzymaticdecarboxylationofcarboxylicacids AT blohjonathanz hydrocarbonsynthesisviaphotoenzymaticdecarboxylationofcarboxylicacids AT vanberkelwillemjh hydrocarbonsynthesisviaphotoenzymaticdecarboxylationofcarboxylicacids AT smithwilsona hydrocarbonsynthesisviaphotoenzymaticdecarboxylationofcarboxylicacids AT hollmannfrank hydrocarbonsynthesisviaphotoenzymaticdecarboxylationofcarboxylicacids |