Cargando…

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer’s Disease

Research on neurodegenerative brain disorders, namely the age-dependent Alzheimer’s disease (AD), has been intensified in the last decade due to the absence of a cure and the recognized increasing of life expectancy for populations. To address the multifactorial nature and complexity of AD, a multi-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rajeshwari, Rajeshwari, Chand, Karam, Candeias, Emanuel, Cardoso, Sandra M., Chaves, Sílvia, Santos, M. Amélia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385087/ https://www.ncbi.nlm.nih.gov/pubmed/30736397 http://dx.doi.org/10.3390/molecules24030587

Ejemplares similares

Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease
por: Fancellu, Gaia, et al.
Publicado: (2019)

Novel multitarget-directed tacrine derivatives as potential candidates for the treatment of Alzheimer’s disease
por: Wu, Wen-Yu, et al.
Publicado: (2017)

Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease
por: Grishchenko, Maria V., et al.
Publicado: (2022)

Multitarget Drug Design, Molecular Docking and PLIF Studies of Novel Tacrine−Coumarin Hybrids for the Treatment of Alzheimer’s Disease
por: Fereidoonnezhad, Masood, et al.
Publicado: (2018)

Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer’s Disease
por: Makhaeva, Galina F., et al.
Publicado: (2023)

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates
por: Piemontese, Luca, et al.
Publicado: (2018)

Novel Donepezil–Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer’s Disease
por: Queda, Fausto, et al.
Publicado: (2021)

Modified Tacrine Derivatives as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease: Synthesis, Biological Evaluation, and Molecular Modeling Study
por: Fares, Salma, et al.
Publicado: (2023)

Merged Tacrine-Based, Multitarget-Directed Acetylcholinesterase Inhibitors 2015–Present: Synthesis and Biological Activity
por: Eckroat, Todd J., et al.
Publicado: (2020)

Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems
por: Fridjonsdottir, Elva, et al.
Publicado: (2021)

Design, Synthesis and Evaluation of Novel Tacrine-Ferulic Acid Hybrids as Multifunctional Drug Candidates against Alzheimer’s Disease
por: Fu, Yingbo, et al.
Publicado: (2016)

Tacrine-Based Hybrids: Past, Present, and Future
por: Bubley, Anna, et al.
Publicado: (2023)

Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer’s Agents: Design, Synthesis and Biological Evaluation
por: Spilovska, Katarina, et al.
Publicado: (2017)

Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease
por: Chen, Yao, et al.
Publicado: (2017)

The Proof-of-Concept of MBA121, a Tacrine–Ferulic Acid Hybrid, for Alzheimer’s Disease Therapy
por: Rodríguez-Ruiz, Emelina R., et al.
Publicado: (2023)

Rivastigmine–Benzimidazole Hybrids as Promising Multitarget Metal-Modulating Compounds for Potential Treatment of Neurodegenerative Diseases
por: Vicente-Zurdo, David, et al.
Publicado: (2023)

First Attempts of the Use of (195)Pt NMR of Phenylbenzothiazole Complexes as Spectroscopic Technique for the Cancer Diagnosis
por: Pereira, Bruna T. L., et al.
Publicado: (2019)

Polymorphism and Mechanochromism in 2-Phenylbenzothiazole Cyclometalated Pt(II) Complexes with Chelating N(∧)O Ligands
por: Gómez de Segura, David, et al.
Publicado: (2022)

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease
por: Chaves, Sílvia, et al.
Publicado: (2020)

Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease
por: Zhu, Jie, et al.
Publicado: (2018)

Design, synthesis and evaluation of OA-tacrine hybrids as cholinesterase inhibitors with low neurotoxicity and hepatotoxicity against Alzheimer’s disease
por: Yang, Huali, et al.
Publicado: (2023)

Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer’s disease therapy
por: Dgachi, Youssef, et al.
Publicado: (2018)

Therapeutic Potential of Multifunctional Tacrine Analogues
por: Przybyłowska, Maja, et al.
Publicado: (2019)

Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer’s Disease Treatment
por: Dakhlaoui, Imen, et al.
Publicado: (2023)

Multitarget therapeutic strategies for Alzheimer’s disease
por: Ibrahim, Mostafa M., et al.
Publicado: (2019)

Selecting Multitarget Peptides for Alzheimer’s Disease
por: Kasus-Jacobi, Anne, et al.
Publicado: (2022)

Improved Multitarget Tracking in Clutter Using Bearings-Only Measurements
por: Shi, Yifang, et al.
Publicado: (2018)

Multitarget Molecular Hybrids of Cinnamic Acids
por: Peperidou, Aikaterini, et al.
Publicado: (2014)

QSAR analysis on tacrine-related acetylcholinesterase inhibitors
por: Wong, Kai Y, et al.
Publicado: (2014)

Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer’s Disease
por: Prati, Federica, et al.
Publicado: (2016)

Formulation, Characterization and Evaluation against SH-SY5Y Cells of New Tacrine and Tacrine-MAP Loaded with Lipid Nanoparticles
por: Silva, Sara, et al.
Publicado: (2020)

Identification and analysis of putative promoter motifs in bovine herpes virus
por: Kurjogi, Mahantesh Mallikrjun, et al.
Publicado: (2012)

Memantine Derivatives as Multitarget Agents in Alzheimer’s Disease
por: Marotta, Giambattista, et al.
Publicado: (2020)

Genome-wide transcriptome profile of rice hybrids with and without Oryza rufipogon introgression reveals candidate genes for yield
por: Guttikonda, Haritha, et al.
Publicado: (2020)

QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer’s Disease Therapy
por: Ramos, Eva, et al.
Publicado: (2019)

Tacrine, Trolox and Tryptoline as Lead Compounds for the Design and Synthesis of Multi-target Agents for Alzheimer’s Disease Therapy
por: Teponnou, Gerard A. K., et al.
Publicado: (2017)

Structural, harmonic force field and vibrational studies of cholinesterase inhibitor tacrine used for treatment of Alzheimer's disease
por: Sundius, Tom, et al.
Publicado: (2023)

Molecular Docking and Pharmacological Investigations of Rivastigmine-Fluoxetine and Coumarin–Tacrine hybrids against Acetyl Choline Esterase
por: Babitha, Pallikkara Pulikkal, et al.
Publicado: (2015)

Effect of Donepezil, Tacrine, Galantamine and Rivastigmine on Acetylcholinesterase Inhibition in Dugesia tigrina
por: Bezerra da Silva, Cristiane, et al.
Publicado: (2016)

Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase
por: Evangelista, Tereza Cristina Santos, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_iu61um4uv80tnp1uar52cci6n4