Photoprotection of Cerium Oxide Nanoparticles against UVA radiation-induced Senescence of Human Skin Fibroblasts due to their Antioxidant Properties

Ultraviolet (UV) irradiation, particularly ultraviolet A (UVA), stimulates reactive oxygen species (ROS) production in the epidermis and dermis, which plays a major part in the photoageing of human skin. Several studies have demonstrated that cerium oxide nanoparticles (CeO(2) NP) can exhibit an ant...

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Autores principales: Li, Yaxi, Hou, Xiaoyang, Yang, Chunsheng, Pang, Yanyu, Li, Xinxin, Jiang, Guan, Liu, Yanqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385175/
https://www.ncbi.nlm.nih.gov/pubmed/30796322
http://dx.doi.org/10.1038/s41598-019-39486-7
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author Li, Yaxi
Hou, Xiaoyang
Yang, Chunsheng
Pang, Yanyu
Li, Xinxin
Jiang, Guan
Liu, Yanqun
author_facet Li, Yaxi
Hou, Xiaoyang
Yang, Chunsheng
Pang, Yanyu
Li, Xinxin
Jiang, Guan
Liu, Yanqun
author_sort Li, Yaxi
collection PubMed
description Ultraviolet (UV) irradiation, particularly ultraviolet A (UVA), stimulates reactive oxygen species (ROS) production in the epidermis and dermis, which plays a major part in the photoageing of human skin. Several studies have demonstrated that cerium oxide nanoparticles (CeO(2) NP) can exhibit an antioxidant effect and free radical scavenging activity. However, the protective role of CeO(2) NP in skin photoageing and the underlying mechanisms are unclear. In this study, we investigated the effects of CeO(2) NP on UVA-irradiated human skin fibroblasts (HSFs) and explored the potential signalling pathway. CeO(2) NP had no apparent cytotoxicity, and could reduce the production of proinflammatory cytokines, intracellular ROS, senescence-associated β-galactosidase activity, and downregulate phosphorylation of c-Jun N-terminal kinases (JNKs) after exposure to UVA radiation. Based on our findings, CeO(2) NPs have great potential against UVA radiation-induced photoageing in HSFs via regulating the JNK signal-transduction pathway to inhibit oxidative stress and DNA damage.
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spelling pubmed-63851752019-02-26 Photoprotection of Cerium Oxide Nanoparticles against UVA radiation-induced Senescence of Human Skin Fibroblasts due to their Antioxidant Properties Li, Yaxi Hou, Xiaoyang Yang, Chunsheng Pang, Yanyu Li, Xinxin Jiang, Guan Liu, Yanqun Sci Rep Article Ultraviolet (UV) irradiation, particularly ultraviolet A (UVA), stimulates reactive oxygen species (ROS) production in the epidermis and dermis, which plays a major part in the photoageing of human skin. Several studies have demonstrated that cerium oxide nanoparticles (CeO(2) NP) can exhibit an antioxidant effect and free radical scavenging activity. However, the protective role of CeO(2) NP in skin photoageing and the underlying mechanisms are unclear. In this study, we investigated the effects of CeO(2) NP on UVA-irradiated human skin fibroblasts (HSFs) and explored the potential signalling pathway. CeO(2) NP had no apparent cytotoxicity, and could reduce the production of proinflammatory cytokines, intracellular ROS, senescence-associated β-galactosidase activity, and downregulate phosphorylation of c-Jun N-terminal kinases (JNKs) after exposure to UVA radiation. Based on our findings, CeO(2) NPs have great potential against UVA radiation-induced photoageing in HSFs via regulating the JNK signal-transduction pathway to inhibit oxidative stress and DNA damage. Nature Publishing Group UK 2019-02-22 /pmc/articles/PMC6385175/ /pubmed/30796322 http://dx.doi.org/10.1038/s41598-019-39486-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Li, Yaxi
Hou, Xiaoyang
Yang, Chunsheng
Pang, Yanyu
Li, Xinxin
Jiang, Guan
Liu, Yanqun
Photoprotection of Cerium Oxide Nanoparticles against UVA radiation-induced Senescence of Human Skin Fibroblasts due to their Antioxidant Properties
title Photoprotection of Cerium Oxide Nanoparticles against UVA radiation-induced Senescence of Human Skin Fibroblasts due to their Antioxidant Properties
title_full Photoprotection of Cerium Oxide Nanoparticles against UVA radiation-induced Senescence of Human Skin Fibroblasts due to their Antioxidant Properties
title_fullStr Photoprotection of Cerium Oxide Nanoparticles against UVA radiation-induced Senescence of Human Skin Fibroblasts due to their Antioxidant Properties
title_full_unstemmed Photoprotection of Cerium Oxide Nanoparticles against UVA radiation-induced Senescence of Human Skin Fibroblasts due to their Antioxidant Properties
title_short Photoprotection of Cerium Oxide Nanoparticles against UVA radiation-induced Senescence of Human Skin Fibroblasts due to their Antioxidant Properties
title_sort photoprotection of cerium oxide nanoparticles against uva radiation-induced senescence of human skin fibroblasts due to their antioxidant properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385175/
https://www.ncbi.nlm.nih.gov/pubmed/30796322
http://dx.doi.org/10.1038/s41598-019-39486-7
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