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Mutations in the palm domain disrupt modulation of acid-sensing ion channel 1a currents by neuropeptides

Modulation by neuropeptides enhances several functions of acid-sensing ion channels (ASICs), such as pain sensation and acid-induced neuronal injury. The acid-induced opening of ASICs is transient, because of a rapid desensitization. Neuropeptides containing an Arg-Phe-amide motif affect ASIC desens...

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Detalles Bibliográficos
Autores principales:	Bargeton, Benoîte, Iwaszkiewicz, Justyna, Bonifacio, Gaetano, Roy, Sophie, Zoete, Vincent, Kellenberger, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385203/ https://www.ncbi.nlm.nih.gov/pubmed/30796301 http://dx.doi.org/10.1038/s41598-018-37426-5

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