Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses

Converting carcinomas in benign oncocytomas has been suggested as a potential anti-cancer strategy. One of the oncocytoma hallmarks is the lack of respiratory complex I (CI). Here we use genetic ablation of this enzyme to induce indolence in two cancer types, and show this is reversed by allowing th...

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Detalles Bibliográficos
Autores principales: Kurelac, Ivana, Iommarini, Luisa, Vatrinet, Renaud, Amato, Laura Benedetta, De Luise, Monica, Leone, Giulia, Girolimetti, Giulia, Umesh Ganesh, Nikkitha, Bridgeman, Victoria Louise, Ombrato, Luigi, Columbaro, Marta, Ragazzi, Moira, Gibellini, Lara, Sollazzo, Manuela, Feichtinger, Rene Gunther, Vidali, Silvia, Baldassarre, Maurizio, Foriel, Sarah, Vidone, Michele, Cossarizza, Andrea, Grifoni, Daniela, Kofler, Barbara, Malanchi, Ilaria, Porcelli, Anna Maria, Gasparre, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385215/
https://www.ncbi.nlm.nih.gov/pubmed/30796225
http://dx.doi.org/10.1038/s41467-019-08839-1

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