Cargando…

Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro

Although the potential of plants extracts to improve feed efficiency and animal productivity and decrease methane emissions by enteric fermentation has been shown, the information available is often contradictory which has been attributed to differences in the complex mixture of bioactive compounds...

Descripción completa

Detalles Bibliográficos
Autores principales: Ramos-Morales, Eva, Tibble-Howlings, Jamie, Lyons, Laura, Ogbu, Magnus O., Murphy, Patrick J., Braganca, Radek, Newbold, Charles James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385227/
https://www.ncbi.nlm.nih.gov/pubmed/30792418
http://dx.doi.org/10.1038/s41598-019-38977-x
_version_ 1783397155383279616
author Ramos-Morales, Eva
Tibble-Howlings, Jamie
Lyons, Laura
Ogbu, Magnus O.
Murphy, Patrick J.
Braganca, Radek
Newbold, Charles James
author_facet Ramos-Morales, Eva
Tibble-Howlings, Jamie
Lyons, Laura
Ogbu, Magnus O.
Murphy, Patrick J.
Braganca, Radek
Newbold, Charles James
author_sort Ramos-Morales, Eva
collection PubMed
description Although the potential of plants extracts to improve feed efficiency and animal productivity and decrease methane emissions by enteric fermentation has been shown, the information available is often contradictory which has been attributed to differences in the complex mixture of bioactive compounds and their interactions. Understanding the degree to which structural features in a compound may affect the biological activity of an extract is essential. We hypothesised that relative small variations in the structure of a compound can have a significant influence on the ability of the derivatives to alter fermentation in the rumen. Nine compounds were synthetized from the natural alkaloid haemanthamine and tested in vitro for their effects on rumen protozoa and fermentation parameters. Our results showed that simple esterifications of haemanthamine or its derivative dihydrohaemanthamine with acetate, butyrate, pivalate or hexanoate led to compounds that differed in their effects on rumen fermentation.
format Online
Article
Text
id pubmed-6385227
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-63852272019-02-26 Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro Ramos-Morales, Eva Tibble-Howlings, Jamie Lyons, Laura Ogbu, Magnus O. Murphy, Patrick J. Braganca, Radek Newbold, Charles James Sci Rep Article Although the potential of plants extracts to improve feed efficiency and animal productivity and decrease methane emissions by enteric fermentation has been shown, the information available is often contradictory which has been attributed to differences in the complex mixture of bioactive compounds and their interactions. Understanding the degree to which structural features in a compound may affect the biological activity of an extract is essential. We hypothesised that relative small variations in the structure of a compound can have a significant influence on the ability of the derivatives to alter fermentation in the rumen. Nine compounds were synthetized from the natural alkaloid haemanthamine and tested in vitro for their effects on rumen protozoa and fermentation parameters. Our results showed that simple esterifications of haemanthamine or its derivative dihydrohaemanthamine with acetate, butyrate, pivalate or hexanoate led to compounds that differed in their effects on rumen fermentation. Nature Publishing Group UK 2019-02-21 /pmc/articles/PMC6385227/ /pubmed/30792418 http://dx.doi.org/10.1038/s41598-019-38977-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ramos-Morales, Eva
Tibble-Howlings, Jamie
Lyons, Laura
Ogbu, Magnus O.
Murphy, Patrick J.
Braganca, Radek
Newbold, Charles James
Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro
title Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro
title_full Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro
title_fullStr Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro
title_full_unstemmed Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro
title_short Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro
title_sort slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385227/
https://www.ncbi.nlm.nih.gov/pubmed/30792418
http://dx.doi.org/10.1038/s41598-019-38977-x
work_keys_str_mv AT ramosmoraleseva slightchangesinthechemicalstructureofhaemanthaminegreatlyinfluencetheeffectofthederivativesonrumenfermentationinvitro
AT tibblehowlingsjamie slightchangesinthechemicalstructureofhaemanthaminegreatlyinfluencetheeffectofthederivativesonrumenfermentationinvitro
AT lyonslaura slightchangesinthechemicalstructureofhaemanthaminegreatlyinfluencetheeffectofthederivativesonrumenfermentationinvitro
AT ogbumagnuso slightchangesinthechemicalstructureofhaemanthaminegreatlyinfluencetheeffectofthederivativesonrumenfermentationinvitro
AT murphypatrickj slightchangesinthechemicalstructureofhaemanthaminegreatlyinfluencetheeffectofthederivativesonrumenfermentationinvitro
AT bragancaradek slightchangesinthechemicalstructureofhaemanthaminegreatlyinfluencetheeffectofthederivativesonrumenfermentationinvitro
AT newboldcharlesjames slightchangesinthechemicalstructureofhaemanthaminegreatlyinfluencetheeffectofthederivativesonrumenfermentationinvitro