Cargando…
Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro
Although the potential of plants extracts to improve feed efficiency and animal productivity and decrease methane emissions by enteric fermentation has been shown, the information available is often contradictory which has been attributed to differences in the complex mixture of bioactive compounds...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385227/ https://www.ncbi.nlm.nih.gov/pubmed/30792418 http://dx.doi.org/10.1038/s41598-019-38977-x |
_version_ | 1783397155383279616 |
---|---|
author | Ramos-Morales, Eva Tibble-Howlings, Jamie Lyons, Laura Ogbu, Magnus O. Murphy, Patrick J. Braganca, Radek Newbold, Charles James |
author_facet | Ramos-Morales, Eva Tibble-Howlings, Jamie Lyons, Laura Ogbu, Magnus O. Murphy, Patrick J. Braganca, Radek Newbold, Charles James |
author_sort | Ramos-Morales, Eva |
collection | PubMed |
description | Although the potential of plants extracts to improve feed efficiency and animal productivity and decrease methane emissions by enteric fermentation has been shown, the information available is often contradictory which has been attributed to differences in the complex mixture of bioactive compounds and their interactions. Understanding the degree to which structural features in a compound may affect the biological activity of an extract is essential. We hypothesised that relative small variations in the structure of a compound can have a significant influence on the ability of the derivatives to alter fermentation in the rumen. Nine compounds were synthetized from the natural alkaloid haemanthamine and tested in vitro for their effects on rumen protozoa and fermentation parameters. Our results showed that simple esterifications of haemanthamine or its derivative dihydrohaemanthamine with acetate, butyrate, pivalate or hexanoate led to compounds that differed in their effects on rumen fermentation. |
format | Online Article Text |
id | pubmed-6385227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63852272019-02-26 Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro Ramos-Morales, Eva Tibble-Howlings, Jamie Lyons, Laura Ogbu, Magnus O. Murphy, Patrick J. Braganca, Radek Newbold, Charles James Sci Rep Article Although the potential of plants extracts to improve feed efficiency and animal productivity and decrease methane emissions by enteric fermentation has been shown, the information available is often contradictory which has been attributed to differences in the complex mixture of bioactive compounds and their interactions. Understanding the degree to which structural features in a compound may affect the biological activity of an extract is essential. We hypothesised that relative small variations in the structure of a compound can have a significant influence on the ability of the derivatives to alter fermentation in the rumen. Nine compounds were synthetized from the natural alkaloid haemanthamine and tested in vitro for their effects on rumen protozoa and fermentation parameters. Our results showed that simple esterifications of haemanthamine or its derivative dihydrohaemanthamine with acetate, butyrate, pivalate or hexanoate led to compounds that differed in their effects on rumen fermentation. Nature Publishing Group UK 2019-02-21 /pmc/articles/PMC6385227/ /pubmed/30792418 http://dx.doi.org/10.1038/s41598-019-38977-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Ramos-Morales, Eva Tibble-Howlings, Jamie Lyons, Laura Ogbu, Magnus O. Murphy, Patrick J. Braganca, Radek Newbold, Charles James Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro |
title | Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro |
title_full | Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro |
title_fullStr | Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro |
title_full_unstemmed | Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro |
title_short | Slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro |
title_sort | slight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385227/ https://www.ncbi.nlm.nih.gov/pubmed/30792418 http://dx.doi.org/10.1038/s41598-019-38977-x |
work_keys_str_mv | AT ramosmoraleseva slightchangesinthechemicalstructureofhaemanthaminegreatlyinfluencetheeffectofthederivativesonrumenfermentationinvitro AT tibblehowlingsjamie slightchangesinthechemicalstructureofhaemanthaminegreatlyinfluencetheeffectofthederivativesonrumenfermentationinvitro AT lyonslaura slightchangesinthechemicalstructureofhaemanthaminegreatlyinfluencetheeffectofthederivativesonrumenfermentationinvitro AT ogbumagnuso slightchangesinthechemicalstructureofhaemanthaminegreatlyinfluencetheeffectofthederivativesonrumenfermentationinvitro AT murphypatrickj slightchangesinthechemicalstructureofhaemanthaminegreatlyinfluencetheeffectofthederivativesonrumenfermentationinvitro AT bragancaradek slightchangesinthechemicalstructureofhaemanthaminegreatlyinfluencetheeffectofthederivativesonrumenfermentationinvitro AT newboldcharlesjames slightchangesinthechemicalstructureofhaemanthaminegreatlyinfluencetheeffectofthederivativesonrumenfermentationinvitro |