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Identification and characterization of a factor Va-binding site on human prothrombin fragment 2

The fragment 2 domain (F2) of prothrombin and its interaction with factor (F) Va is known to contribute significantly to prothrombinase-catalyzed activation of prothrombin. The extent to which the F2-FVa interaction affects the overall thrombin generation, however, is uncertain. To study this intera...

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Detalles Bibliográficos
Autores principales:	Friedmann, Alexander P., Koutychenko, Anatoli, Wu, Chengliang, Fredenburgh, James C., Weitz, Jeffrey I., Gross, Peter L., Xu, Ping, Ni, Feng, Kim, Paul Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385242/ https://www.ncbi.nlm.nih.gov/pubmed/30792421 http://dx.doi.org/10.1038/s41598-019-38857-4

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