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Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity

There are currently no therapeutics to treat infection with the alphavirus Venezuelan equine encephalitis virus (VEEV), which causes flu-like symptoms leading to neurological symptoms in up to 14% of cases. Large outbreaks of VEEV can result in 10,000 s of human cases and mass equine death. We previ...

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Detalles Bibliográficos
Autores principales:	DeBono, Aaron, Thomas, David R., Lundberg, Lindsay, Pinkham, Chelsea, Cao, Ying, Graham, J. Dinny, Clarke, Christine L., Wagstaff, Kylie M., Shechter, Sharon, Kehn-Hall, Kylene, Jans, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385310/ https://www.ncbi.nlm.nih.gov/pubmed/30796232 http://dx.doi.org/10.1038/s41598-019-38671-y

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