Increased susceptibility of airway epithelial cells from ataxia-telangiectasia to S. pneumoniae infection due to oxidative damage and impaired innate immunity

Respiratory disease is a major cause of morbidity and mortality in patients with ataxia-telangiectasia (A-T) who are prone to recurrent sinopulmonary infections, bronchiectasis, pulmonary fibrosis, and pulmonary failure. Upper airway infections are common in patients and S. pneumoniae is associated...

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Detalles Bibliográficos
Autores principales: Yeo, Abrey J., Henningham, Anna, Fantino, Emmanuelle, Galbraith, Sally, Krause, Lutz, Wainwright, Claire E., Sly, Peter D., Lavin, Martin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385340/
https://www.ncbi.nlm.nih.gov/pubmed/30796268
http://dx.doi.org/10.1038/s41598-019-38901-3

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