Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1

The G-protein bile acid receptor 1 (GPBAR1) has emerged in the last decade as prominent target for the treatment of metabolic and inflammatory diseases including type 2 diabetes, obesity, and non-alcoholic steatohepatitis. To date numerous bile acid derivatives have been identified as GPBAR1 agonist...

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Detalles Bibliográficos
Autores principales: Di Leva, Francesco Saverio, Festa, Carmen, Carino, Adriana, De Marino, Simona, Marchianò, Silvia, Di Marino, Daniele, Finamore, Claudia, Monti, Maria Chiara, Zampella, Angela, Fiorucci, Stefano, Limongelli, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385358/
https://www.ncbi.nlm.nih.gov/pubmed/30792450
http://dx.doi.org/10.1038/s41598-019-38840-z

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