Cargando…

Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway

BACKGROUND: Drug resistance is common in cancer chemotherapy. This study investigates the role of Glycerol kinase 5 (GK5) in mediating gefitinib resistance in NSCLC. METHODS: The exosomal mRNA of GK5 was detected using a tethered cationic lipoplex nanoparticle (TCLN) biochip. Real-time PCR and Weste...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Jian, Qu, Guimei, Zhang, Ge, Wu, Zuoren, Liu, Jing, Yang, Dawei, Li, Jing, Chang, Meijia, Zeng, Hengshan, Hu, Jie, Fang, Tao, Song, Yuanlin, Bai, Chunxue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385389/ https://www.ncbi.nlm.nih.gov/pubmed/30791926 http://dx.doi.org/10.1186/s13046-019-1057-7

Ejemplares similares

Calpain 2 knockdown promotes cell apoptosis and restores gefitinib sensitivity through epidermal growth factor receptor/protein kinase B/survivin signaling
por: Zhang, Ge, et al.
Publicado: (2018)

Knockdown of PLAT enhances the anticancer effect of gefitinib in non-small cell lung cancer
por: Yan, Mengnan, et al.
Publicado: (2020)

Knockdown of annexin A5 restores gefitinib sensitivity by promoting G2/M cell cycle arrest
por: Zhou, Jian, et al.
Publicado: (2018)

Lipidomics reveals that sustained SREBP-1-dependent lipogenesis is a key mediator of gefitinib-acquired resistance in EGFR-mutant lung cancer
por: Xu, Chuncao, et al.
Publicado: (2021)

Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope With Increased Storage Demands of Obesity
por: Carobbio, Stefania, et al.
Publicado: (2013)

Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells
por: Li, Jiajin, et al.
Publicado: (2016)

RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway
por: Wang, Guangchuan, et al.
Publicado: (2019)

High-throughput single-EV liquid biopsy: Rapid, simultaneous, and multiplexed detection of nucleic acids, proteins, and their combinations
por: Zhou, Jian, et al.
Publicado: (2020)

TGF-β1 promotes SCD1 expression via the PI3K-Akt-mTOR-SREBP1 signaling pathway in lung fibroblasts
por: Zhou, Zili, et al.
Publicado: (2023)

α-Tocopherol-13′-Carboxychromanol Induces Cell Cycle Arrest and Cell Death by Inhibiting the SREBP1-SCD1 Axis and Causing Imbalance in Lipid Desaturation
por: Liao, Sijia, et al.
Publicado: (2023)

Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutatnt colorectal cancer
por: Chen, Hao, et al.
Publicado: (2022)

Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells
por: Yang, Nian, et al.
Publicado: (2019)

BACE1 and SCD1 are associated with neurodegeneration
por: Bedoya-Guzmán, Ferley A., et al.
Publicado: (2023)

miR-762 activation confers acquired resistance to gefitinib in non-small cell lung cancer
por: Ge, Peng, et al.
Publicado: (2019)

SREBP1 regulates Lgals3 activation in response to cholesterol loading
por: Li, Jing, et al.
Publicado: (2022)

GLIPR1 modulates the response of cisplatin-resistant human lung cancer cells to cisplatin
por: Gong, Xin, et al.
Publicado: (2017)

Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1
por: Torres-Ayuso, P, et al.
Publicado: (2015)

Prospect and application of Internet of Things technology for prevention of SARIs
por: Song, Yuanlin, et al.
Publicado: (2020)

SCD1, autophagy and cancer: implications for therapy
por: Ascenzi, Francesca, et al.
Publicado: (2021)

Berberine Regulated Gck, G6pc, Pck1 and Srebp-1c Expression and Activated AMP-activated Protein Kinase in Primary Rat Hepatocytes
por: Ge, Yuebin, et al.
Publicado: (2011)

Obesity-Induced Upregulation of ZBTB7A Promotes Lipid Accumulation through SREBP1
por: Zhou, Jing-ping, et al.
Publicado: (2020)

An integrated analysis of dysregulated SCD1 in human cancers and functional verification of miR-181a-5p/SCD1 axis in esophageal squamous cell carcinoma
por: Wang, Bing-Yen, et al.
Publicado: (2023)

Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice
por: Rong, Shunxing, et al.
Publicado: (2017)

Inhibition of SREBP1 sensitizes cells to death ligands
por: Eberhard, Yanina, et al.
Publicado: (2011)

Impact of silencing hepatic SREBP-1 on insulin signaling
por: Jideonwo, Victoria, et al.
Publicado: (2018)

SREBP2 inhibitor betulin sensitizes hepatocellular carcinoma to lenvatinib by inhibiting the mTOR/IL-1β pathway: SREBP2 Inhibitor sensitizes HCC to lenvatinib
por: Fan, Minghao, et al.
Publicado: (2023)

HCBP6 upregulates human SREBP1c expression by binding to C/EBPβ-binding site in the SREBP1c promoter
por: Yang, Xueliang, et al.
Publicado: (2018)

The Aurora Kinase Inhibitor TAK901 Inhibits Glioblastoma Growth by Blocking SREBP1-Mediated Lipid Metabolism
por: Zhan, Xiudan, et al.
Publicado: (2022)

New insights of aquaporin 5 in the pathogenesis of high altitude pulmonary edema
por: She, Jun, et al.
Publicado: (2013)

The Chromatin Remodeling Protein BRG1 Regulates SREBP Maturation by Activating SCAP Transcription in Hepatocytes
por: Kong, Ming, et al.
Publicado: (2021)

World Coalition on SCD launches, sparking global focus on SCD diagnosis and care
por: Zapfel, Andrew, et al.
Publicado: (2023)

Structural Basis for the Inhibition of Cyclin G‐Associated Kinase by Gefitinib
por: Ohbayashi, Naomi, et al.
Publicado: (2018)

Combined treatment with N‐acetylcysteine and gefitinib overcomes drug resistance to gefitinib in NSCLC cell line
por: Li, Jun, et al.
Publicado: (2019)

Prognostic Impact of PCK1 Protein Kinase Activity-Dependent Nuclear SREBP1 Activation in Non-Small-Cell Lung Carcinoma
por: Shao, Fei, et al.
Publicado: (2021)

Ndufa6 regulates adipogenic differentiation via Scd1
por: Zhang, Jingwei, et al.
Publicado: (2021)

SCD1 deficiency exacerbates osteoarthritis by inducing ferroptosis in chondrocytes
por: Yu, Chao, et al.
Publicado: (2023)

TAK1 regulates hepatic lipid homeostasis through SREBP
por: Morioka, Sho, et al.
Publicado: (2016)

Induction of Lipin1 by ROS-Dependent SREBP-2 Activation
por: Seo, Kyuhwa, et al.
Publicado: (2017)

Targeting SREBP-1-Mediated Lipogenesis as Potential Strategies for Cancer
por: Zhao, Qiushi, et al.
Publicado: (2022)

Pivotal role of human stearoyl-CoA desaturases (SCD1 and 5) in breast cancer progression: oleic acid-based effect of SCD1 on cell migration and a novel pro-cell survival role for SCD5
por: Angelucci, Cristiana, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_hh2o8phck03ivia8rjn3c6hgma