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Inflammation-induced hypoparathyroidism triggered by combination immune checkpoint blockade for melanoma

BACKGROUND: Treatment with a combination of PD-1 and CTLA-4 targeted checkpoint inhibition has improved outcome of melanoma patients and led to durable remissions but is also associated with significant toxicities. Endocrinopathies such as thyroiditis and hypophysitis are often seen, but other, rare...

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Detalles Bibliográficos
Autores principales: Trinh, Beckey, Sanchez, Guacimara Ortega, Herzig, Petra, Läubli, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385398/
https://www.ncbi.nlm.nih.gov/pubmed/30791949
http://dx.doi.org/10.1186/s40425-019-0528-x