Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats

BACKGROUND: Subarachnoid hemorrhage (SAH) is a life-threatening subtype of stroke with high mortality and disabilities. Retinoid X receptor (RXR) has been shown to be neuroprotective against ischemia/reperfusion injury. This study aimed to investigate the effects of the selective RXR agonist bexarot...

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Detalles Bibliográficos
Autores principales: Zuo, Yuchun, Huang, Lei, Enkhjargal, Budbazar, Xu, Weilin, Umut, Ocak, Travis, Zachary D., Zhang, Guangyu, Tang, Jiping, Liu, Fei, Zhang, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385420/
https://www.ncbi.nlm.nih.gov/pubmed/30791908
http://dx.doi.org/10.1186/s12974-019-1432-5

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