Myopia disease mouse models: a missense point mutation (S673G) and a protein-truncating mutation of the Zfp644 mimic human disease phenotype

Zinc finger 644 (Zfp644 in mouse, ZNF644 in human) gene is a transcription factor whose mutation S672G is considered a potential genetic factor of inherited high myopia. ZNF644 interacts with G9a/GLP complex, which functions as a H3K9 methyltransferase to silence transcription. In this study, we gen...

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Detalles Bibliográficos
Autores principales: Szczerkowska, Katarzyna I., Petrezselyova, Silvia, Lindovsky, Jiri, Palkova, Marcela, Dvorak, Jan, Makovicky, Peter, Fang, Mingyan, Jiang, Chongyi, Chen, Lingyan, Shi, Mingming, Liu, Xiao, Zhang, Jianguo, Kubik-Zahorodna, Agnieszka, Schuster, Bjoern, Beck, Inken M., Novosadova, Vendula, Prochazka, Jan, Sedlacek, Radislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385473/
https://www.ncbi.nlm.nih.gov/pubmed/30834109
http://dx.doi.org/10.1186/s13578-019-0280-4

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