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Materials and structures used in meniscus repair and regeneration: a review

Meniscus is a vital functional unit in knee joint. It acts as a lubricating structure, a nutrient transporting structure, as well as shock absorber during jumping, twisting and running and offers stability within the knee joint. It helps in load distribution, in bearing the tensile hoop stresses and...

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Autores principales: Vadodaria, Ketankumar, Kulkarni, Abhilash, Santhini, E, Vasudevan, Prakash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: EDP Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385612/
https://www.ncbi.nlm.nih.gov/pubmed/30794149
http://dx.doi.org/10.1051/bmdcn/2019090102
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author Vadodaria, Ketankumar
Kulkarni, Abhilash
Santhini, E
Vasudevan, Prakash
author_facet Vadodaria, Ketankumar
Kulkarni, Abhilash
Santhini, E
Vasudevan, Prakash
author_sort Vadodaria, Ketankumar
collection PubMed
description Meniscus is a vital functional unit in knee joint. It acts as a lubricating structure, a nutrient transporting structure, as well as shock absorber during jumping, twisting and running and offers stability within the knee joint. It helps in load distribution, in bearing the tensile hoop stresses and balancing by providing a cushion effect between hard surfaces of two bones. Meniscus may be injured in sports, dancing, accident or any over stressed condition. Any meniscal lesion can lead to a gradual development of osteoarthritis or erosion of bone contact surface due to disturbed load and contact stress distribution caused by injury/pain. Once injured, the possibilities of self-repair are rare in avascular region of meniscus, due to lack of blood supply in avascular region. Meniscus has vascular and avascular regions in structure. Majority of the meniscus parts turn avascular with increase in age. Purpose of this review is to highlight advances in meniscus repair with special focus on tissue engineering using textile/fiber based scaffolds, as well as the recent technical advances in scaffolds for meniscus recon- struction/ regeneration treatment.
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spelling pubmed-63856122019-03-01 Materials and structures used in meniscus repair and regeneration: a review Vadodaria, Ketankumar Kulkarni, Abhilash Santhini, E Vasudevan, Prakash Biomedicine (Taipei) Review Article Meniscus is a vital functional unit in knee joint. It acts as a lubricating structure, a nutrient transporting structure, as well as shock absorber during jumping, twisting and running and offers stability within the knee joint. It helps in load distribution, in bearing the tensile hoop stresses and balancing by providing a cushion effect between hard surfaces of two bones. Meniscus may be injured in sports, dancing, accident or any over stressed condition. Any meniscal lesion can lead to a gradual development of osteoarthritis or erosion of bone contact surface due to disturbed load and contact stress distribution caused by injury/pain. Once injured, the possibilities of self-repair are rare in avascular region of meniscus, due to lack of blood supply in avascular region. Meniscus has vascular and avascular regions in structure. Majority of the meniscus parts turn avascular with increase in age. Purpose of this review is to highlight advances in meniscus repair with special focus on tissue engineering using textile/fiber based scaffolds, as well as the recent technical advances in scaffolds for meniscus recon- struction/ regeneration treatment. EDP Sciences 2019-02-22 /pmc/articles/PMC6385612/ /pubmed/30794149 http://dx.doi.org/10.1051/bmdcn/2019090102 Text en © Author(s) 2019. This article is published with open access by China Medical University Open Access This article is distributed under terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) which permits any use, distribution, and reproduction in any medium, provided original author(s) and source are credited.
spellingShingle Review Article
Vadodaria, Ketankumar
Kulkarni, Abhilash
Santhini, E
Vasudevan, Prakash
Materials and structures used in meniscus repair and regeneration: a review
title Materials and structures used in meniscus repair and regeneration: a review
title_full Materials and structures used in meniscus repair and regeneration: a review
title_fullStr Materials and structures used in meniscus repair and regeneration: a review
title_full_unstemmed Materials and structures used in meniscus repair and regeneration: a review
title_short Materials and structures used in meniscus repair and regeneration: a review
title_sort materials and structures used in meniscus repair and regeneration: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385612/
https://www.ncbi.nlm.nih.gov/pubmed/30794149
http://dx.doi.org/10.1051/bmdcn/2019090102
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